The Immunology of Psoriasis—Current Concepts in Pathogenesis

I Sieminska, M Pieniawska, TM Grzywa - Clinical Reviews in Allergy & …, 2024 - Springer
Psoriasis is one of the most common inflammatory skin diseases with a chronic, relapsing-
remitting course. The last decades of intense research uncovered a pathological network of …

The neonatal immune system and respiratory pathogens

CJ Sedney, ET Harvill - Microorganisms, 2023 - mdpi.com
Neonates are more susceptible to some pathogens, particularly those that cause infection in
the respiratory tract. This is often attributed to an incompletely developed immune system …

Single-cell multi-omics reveal stage of differentiation and trajectory-dependent immunity-related gene expression patterns in human erythroid cells

R Perik-Zavodskii, O Perik-Zavodskaia… - Frontiers in …, 2024 - frontiersin.org
The role of Erythroid cells in immune regulation and immunosuppression is one of the
emerging topics in modern immunology that still requires further clarification as Erythroid …

OATD-02 validates the benefits of pharmacological inhibition of arginase 1 and 2 in cancer

MM Grzybowski, PS Stańczak, P Pomper, R Błaszczyk… - Cancers, 2022 - mdpi.com
Simple Summary Arginase 1 and 2 are drivers of multiple immunosuppressive mechanisms
and tumour-specific metabolic adaptations. Pharmacological inhibition of extracellular ARG1 …

A subpopulation of human bone marrow erythroid cells displays a myeloid gene expression signature similar to that of classic monocytes

R Perik-Zavodskii, O Perik-Zavodskaia, J Shevchenko… - PloS one, 2024 - journals.plos.org
Erythroid cells, serving as progenitors and precursors to erythrocytes responsible for oxygen
transport, were shown to exhibit an immunosuppressive and immunoregulatory phenotype …

Immunoregulatory properties of erythroid nucleated cells induced from CD34+ progenitors from bone marrow

JA Shevchenko, RY Perik-Zavodskii, KV Nazarov… - Plos one, 2023 - journals.plos.org
CD 71+ erythroid nucleated cells have pronounced immunoregulatory properties in normal
and pathological conditions. Many populations of cells with immunoregulatory properties are …

Murine Bone Marrow Erythroid Cells Have Two Branches of Differentiation Defined by the Presence of CD45 and a Different Immune Transcriptome Than Fetal Liver …

O Perik-Zavodskaia, R Perik-Zavodskii… - International Journal of …, 2023 - mdpi.com
Mouse erythropoiesis is a multifaceted process involving the intricate interplay of
proliferation, differentiation, and maturation of erythroid cells, leading to significant changes …

Oncogenic Calreticulin Induces Immune Escape by Stimulating TGF-β Expression and Regulatory T Cell Expansion in the Bone Marrow Microenvironment

D Schmidt, C Endres, R Hoefflin, G Andrieux, M Zwick… - Cancer Research, 2024 - AACR
Increasing evidence supports the interplay between oncogenic mutations and immune
escape mechanisms. Strategies to counteract the immune escape mediated by oncogenic …

Novel orally bioavailable piperidine derivatives as extracellular arginase inhibitors developed by a ring expansion

A Gzik, B Borek, J Chrzanowski, K Jedrzejczak… - European Journal of …, 2024 - Elsevier
Arginase is a multifaced enzyme that plays an important role in health and disease being
regarded as a therapeutic target for the treatment of various pathological states such as …

Targeting erythroid progenitor cells for cancer immunotherapy

SR Li, ZZ Wu, HJ Yu, ZJ Sun - International Journal of Cancer, 2024 - Wiley Online Library
Immunotherapy, especially immune checkpoint blockade therapy, represents a major
milestone in the history of cancer therapy. However, the current response rate to …