The provision of pure enantiomers is of increasing importance not only for the
pharmaceutical industry but also for agrochemistry and biotechnology. In general, there are …

To many, periodic mechanical conformational motion of molecules is mesmerizing to a
degree that is difficult to explain rationally: It is almost as hard to stop watching an image of …

Abstract Bicyclic hydrocarbons, and bicyclo [1.1. 1] pentanes (BCPs) in particular, are
playing an emerging role as saturated bioisosteres in pharmaceutical, agrochemical and …

This study reports the catalytic deracemization of ketones bearing stereocenters in the α-
position in a single reaction via deprotonation, followed by enantioselective protonation. The …

Under oxidative conditions, 1, 4-dihydropyridines (DHPs) undergo a homolytic cleavage,
forming exclusively a Csp3-centered radical that can engage in the C–H alkylation of …

Biocatalysis is an enabling technology adding to organic oxidation chemistry. Especially the
high selectivity of enzymatic oxidation coevally operating under mild conditions and not …

Interest in green chemistry and clean processes has grown so much in recent years that
topics such as fluorous biphasic catalysis, metal organic frameworks, and process …

This book details chiroptical spectroscopic methods: electronic circular dichroism (ECD),
optical rotatory dispersion (ORD), vibrational circular dichroism (VCD), and vibrational …

The broad utility of cyclic structures accounts for the key roles that cycle-forming reactions
play in synthetic designs. Most of these reactions can be classified as either a cyclization of …

A systematic study of general trends in σ acceptor properties of C− X bonds where X is a
main group element from groups IVa− IIa is presented. The acceptor ability of the C− X σ …