Cellular conditions responsible for methylmercury-mediated neurotoxicity

M Fujimura, F Usuki - International Journal of Molecular Sciences, 2022 - mdpi.com
Methylmercury (MeHg) is a widely known environmental pollutant that causes severe
neurotoxicity. MeHg-induced neurotoxicity depends on various cellular conditions, including …

Investigating how explicit contextual cues affect predictive sensorimotor control in autistic adults

T Arthur, M Brosnan, D Harris, G Buckingham… - Journal of Autism and …, 2023 - Springer
Research suggests that sensorimotor difficulties in autism could be reduced by providing
individuals with explicit contextual information. To test this, we examined autistic visuomotor …

Cerebellar state estimation enables resilient coupling across behavioural domains

ER Palacios, P Chadderton, K Friston, C Houghton - Scientific Reports, 2024 - nature.com
Cerebellar computations are necessary for fine behavioural control and may rely on internal
models for estimation of behaviourally relevant states. Here, we propose that the central …

GlyT2-positive interneurons regulate timing and variability of information transfer in a cerebellar-behavioural loop

ER Palacios, C Houghton, P Chadderton - Journal of Neuroscience, 2024 - jneurosci.org
GlyT2-positive interneurons, Golgi and Lugaro cells, reside in the input layer of the
cerebellar cortex in a key position to influence information processing. Here, we examine the …

NR1 Splicing Variant NR1a in Cerebellar Granule Neurons Constitutes a Better Motor Learning in the Mouse

T Tan, L Jiang, Z He, X Ding, X Xiong, M Tang, Y Chen… - The Cerebellum, 2024 - Springer
As an excitatory neuron in the cerebellum, the granule cells play a crucial role in motor
learning. The assembly of NMDAR in these neurons varies in developmental stages, while …

Information Processing in the Cerebellum

C Houghton, P Isope, R Apps… - Frontiers in Systems …, 2021 - frontiersin.org
The cerebellum is involved in a wide range of behaviors including the coordination of reflex
and voluntary movements, postural adjustments to maintain balance, and the learning of …

[图书][B] Sensorimotor Differences in Autism Spectrum Disorder: An Evaluation of Potential Mechanisms

TG Arthur - 2021 - search.proquest.com
This thesis examined the aetiology of sensorimotor impairments in Autism Spectrum
Disorder: a neurodevelopmental condition that affects an individual's sociobehavioural …

A comprehensive study on the cognitive mechanisms and neural substrates of hallucination proneness

JF Johnson - 2022 - cris.maastrichtuniversity.nl
In order to perceive the world around us, and to successfully interact within it and with other
actors, we must be able to predict the causes of our sensations. However, abnormal …

Dopaminergic signalling during goal-directed behaviour in a structured environment

M Blanco Pozo - 2022 - ora.ox.ac.uk
During flexible behaviour, dopamine is thought to carry reward prediction errors (RPEs),
which update values and hence modify future behaviour. However, in real-world situations …

[PDF][PDF] Contribution of cerebellar sensorimotor representations to behaviour

ER Palacios, ER Palacios - Clinical and …, 1998 - research-information.bris.ac.uk
The cerebellum is important for behavioural control. It is not necessary for the generation of
behaviour, but it is critical for its fluency and coordination. Its computations are often …