Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …

The structure of neuronal circuits that subserve cognitive functions in the brain is shaped
and refined throughout development and into adulthood. Evidence from human and animal …

The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …

In the developing brain, dendrite branches and dendritic spines form and turn over
dynamically. By contrast, most dendrite arbors and dendritic spines in the adult brain are …

Synapses are specialized cell–cell contacts that mediate communication between neurons.
Most excitatory synapses in the brain are housed on dendritic spines, small actin-rich …

Activity-regulated gene expression is believed to play a key role in the development and
refinement of neuronal circuitry. Nevertheless, the transcriptional networks that regulate …

Dendritic spines are specialized structures on neuronal processes where the majority of
excitatory synapses are localized. Spines are highly dynamic, and their stabilization and …

Memory impairments are associated with many brain disorders such as autism, Alzheimer's
disease, and depression. Forming memories involves modifications of synaptic transmission …

Neurotransmitter receptor density is a major variable in regulating synaptic strength.
Receptors rapidly exchange between synapses and intracellular storage pools through …

Neural plasticity plays a critical role in mediating short‐and long‐term brain responses to
environmental stimuli. A major effector of plasticity throughout many regions of the brain is …