Nose-to-brain drug delivery has been of great interest for the treatment of many central
nervous system (CNS) diseases and psychiatric disorders over past decades. Several …

The treatment of neurodegenerative and psychiatric disorders remains a challenge in
medical research. Several strategies have been developed over the years, either to …

Curcumin (CUR) has antioxidant and anti-inflammatory effects that are beneficial to
Alzheimer's disease (AD). However, the poor solubility and high instability of CUR …

Intravenous delivery of nanomaterials containing therapeutic agents and various cargos for
treating neurological disorders is often constrained by low delivery efficacy due to difficulties …

Intranasal administration is a promising route for brain drug delivery. However, it can be
difficult to formulate drugs that have low water solubility into high strength intranasal …

Highlights•NTB drug delivery is emerging as a novel approach for the treatment of CNS
diseases.•DTE and DTP are two main indexes used to evaluate NTB delivery.•A quantitative …

Nano-structured lipid carriers containing zopiclone were prepared as a targeted drug
delivery system to convey zopiclone directly to brain via nasal route. Nano-structured lipid …

Highlights•Nanoemulsions are among promising nanocarriers for various biomedical
applications.•Biocompatibility and simplicity are the most important advantages of …

Haloperidol (Hal) is one of the widely used antipsychotic drugs. When orally administered, it
suffers from low bioavailability due to hepatic first pass metabolism. This study aimed at …

Purpose The research objective is to design intranasal brain targeted CLZ loaded lecithin
based polymeric micelles (CLZ-LbPM) aiming to improve central systemic CLZ …