Significance: Ionizing radiation is a vital component in the oncologist's arsenal for the
treatment of cancer. Approximately 50% of all cancer patients will receive some form of …

DNA damage by endogenous and exogenous agents is a serious concern, as the damaged
products can affect genome integrity severely. Damage to DNA may arise from various …

Understanding the details of DNA damage caused by high-energy particles or photons is
complicated by the multitude of reactive species, arising from the ionization and dissociation …

The presence of gold nanoparticles (AuNPs) greatly enhances the formation of DNA
damage when exposed to therapeutic X-rays. Three types of DNA damage are assessed in …

Studying the ultrafast dynamics of ionized aqueous biomolecules is important for gaining an
understanding of the interaction of ionizing radiation with biological matter. Guanine plays …

The aim of this study was to investigate the protective effect of root extract of Withania
somnifera (WS) against gamma-irradiation-induced oxidative stress and DNA damage in …

One of the most distinguished features in biological effects of heavy ions would be the
decrease of oxygen effect in the high-LET region. This feature has been referred to as the …

It has long been assumed that the population of radicals trapped in irradiated DNA (that is,
the radicals escaping recombination) would quantitatively account for the lesions observed …

Nucleobase radicals are the major intermediates generated by the direct (eg, dA•+) and
indirect (eg, dA•) effects of γ-radiolysis. dA• was independently generated in DNA for the first …

We measured the yield and spectrum of strand breaks and nucleobase lesions produced in
fully hydrated plasmid DNA films to determine the linear energy transfer (LET) dependence …