Cholesterol homeostasis is maintained through the coordinated regulation of the trafficking,
biosynthesis, absorption, and efflux of cholesterol. From the discovery that atherosclerotic …

Cholestasis, a hallmark feature of hepatobiliary disease, is characterized by the retention of
biliary constituents. Some of these constituents, such as bile acids, inflict damage to …

Intestinal absorption is an important contributor to systemic cholesterol homeostasis.
Niemann-Pick C1 Like 1 (NPC1L1) assists in the initial step of dietary cholesterol uptake, but …

Background & aims: Oleanolic acid is abundantly distributed in Swertia mussotii Franch, a
Chinese traditional herb for the treatment of jaundice. However, the hepatoprotective role of …

Purpose The antifungal drugs ketoconazole and itraconazole reduce serum concentrations
of 4β-hydroxycholesterol, which is a validated marker for hepatic cytochrome P450 (CYP) …

Swertianlarin, isolated from Swertia mussotii Franch and Enicostemma axillare, has
hepatoprotective effects against cholestasis in rat models of hepatotoxicity. However, the …

Bile flow in the liver is driven by active transport of organic ions across the canalicular
membrane of hepatocytes, followed by secretion of water in the bile ductules. Liver lobules …

A number of statins, the cholesterol-lowering drugs, inhibit the in vitro replication of hepatitis
C virus (HCV). In HCV-infected patients, addition of statins to the earlier standard of care …

Cancer is one of the most leading causes of morbidity and mortality worldwide causing 9.6
million deaths in 2018. However, for a variety of cancers the efficacy of current standard …

The multidrug/multixenobiotic resistance (MDR/MXR) mechanism is a cellular response
involving the induction and coordinated action of the ATP-binding cassette (ABC) …