Metaplastic breast cancer (MpBC) is an exceedingly rare breast cancer variant that is
therapeutically challenging and aggressive. MpBC is defined by the histological presence of …

The benefit of integrating batches of genomic data to increase statistical power is often
hindered by batch effects, or unwanted variation in data caused by differences in technical …

Metaplastic breast carcinoma (MBC) is a heterogeneous group of infrequent invasive
carcinomas that display differentiation of the neoplastic epithelium towards squamous cells …

Spatially resolved gene expression profiling provides insight into tissue organization and
cell–cell crosstalk; however, sequencing-based spatial transcriptomics (ST) lacks single-cell …

Abstract Purpose: Metaplastic breast cancer (MpBC) is a rare subtype of breast cancer that
is commonly triple-negative and poorly responsive to neoadjuvant therapy in retrospective …

Background Variability in datasets is not only the product of biological processes: they are
also the product of technical biases. ComBat and ComBat-Seq are among the most widely …

Triple‐negative breast cancer (TNBC) is the most aggressive breast cancer subtype and
lacks specific targeted therapeutic agents. The current mechanistic evidence from cell …

Metaplastic breast carcinoma (MBC) is a heterogeneous group of infrequent triple negative
(TN) invasive carcinomas with poor prognosis. MBCs have a different clinical behavior from …

Rationale: Alternative therapeutic strategies based on tumor-specific molecular targets are
urgently needed for triple-negative breast cancer (TNBC). The protease cathepsin D (cath …

Identification of biomarkers is essential for the diagnosis and prognosis of certain diseases,
like cancer. Gene selection purpose is finding the minimum number of genes that can …