Chronic pain is a debilitating condition that influences the social, economic, and
psychological aspects of patients' lives. Hence, the need for better treatment is drawing …

Chronic pain is among the most disabling and costly disorders, with prevalence ranging
from 10% to 55%. However, current therapeutic strategies for chronic pain are unsatisfactory …

Previously, we showed that activation of the spinal CXCL9, 10/CXCR3 pathway mediated
bone cancer pain (BCP) in rats. However, the cellular mechanism involved is poorly …

Background Dexmedetomidine (DEX) has been used under perioperative settings as an
adjuvant to enhance the analgesic property of local anesthetics by some anesthesiologists …

Synapses are specialized cell-cell junctions that underlie the function of neural circuits by
mediating communication between neurons. Both the formation and function of synapses …

Synapse formation between neurons is critical for proper circuit and brain function. Prior to
activity-dependent refinement of connections between neurons, activity-independent cues …

The acetic acid and phenyl-p-benzoquinone are easy and fast screening models to access
the activity of novel candidates as analgesic drugs and their mechanisms. These models …

The assembly and function of neuronal circuits rely on selective cell–cell interactions to
control axon targeting, generate pre-and postsynaptic specialization and recruit …

It was previously shown that EphB/ephrinB reverse signaling in retinal ganglion cells
(RGCs) is activated and involved in RGC apoptosis in a rat chronic ocular hypertension …

There is accumulating evidence to implicate the importance of EphBs receptors and
ephrinBs ligands were involved in modulation of spinal nociceptive information. However …