Potential therapeutic benefits of strategies directed to mitochondria
AKS Camara, EJ Lesnefsky… - Antioxidants & redox …, 2010 - liebertpub.com
The mitochondrion is the most important organelle in determining continued cell survival
and cell death. Mitochondrial dysfunction leads to many human maladies, including …
and cell death. Mitochondrial dysfunction leads to many human maladies, including …
Targeting hypertension with a new adenosine triphosphate–sensitive potassium channel opener iptakalim
ZY Pan, JH Huang, WY Cui, CL Long… - Journal of …, 2010 - journals.lww.com
Hypertension is the most common cardiovascular disease. The discovery of the
antihypertensive action of adenosine triphosphate-sensitive potassium (K ATP) channel …
antihypertensive action of adenosine triphosphate-sensitive potassium (K ATP) channel …
Effects of obesity on vascular potassium channels
This review is focused on the effects of obesity on function and expression of potassium (K)
channels in the vasculature. Five families of K channels have been identified in the vascular …
channels in the vasculature. Five families of K channels have been identified in the vascular …
Iptakalim protects against hypoxic brain injury through multiple pathways associated with ATP-sensitive potassium channels
HL Zhu, WQ Luo, H Wang - Neuroscience, 2008 - Elsevier
The rapid and irreversible brain injury produced by anoxia when stroke occurs is well
known. Cumulative evidence suggests that the activation of neuronal ATP-sensitive …
known. Cumulative evidence suggests that the activation of neuronal ATP-sensitive …
Review on regulation of inwardly rectifying potassium channels
J Wang, Y Huang, Q Ning - Critical Reviews™ in Eukaryotic …, 2011 - dl.begellhouse.com
An inwardly rectifying potassium channel (Kir) is a kind of protein complex that is widely
expressed on excitable and nonexcitable cell membranes. Kir channels serve important …
expressed on excitable and nonexcitable cell membranes. Kir channels serve important …
Structural nucleotide analogs are potent activators/inhibitors of pancreatic β cell KATP channels: an emerging mechanism supporting their use as antidiabetic drugs
D Tricarico, JF Rolland, G Cannone, A Mele… - … of Pharmacology and …, 2012 - ASPET
The 2 H-1, 4-benzoxazine derivatives are novel drugs structurally similar to nucleotides;
however, their actions on the pancreatic β cell ATP-sensitive K+ (KATP) channel and on …
however, their actions on the pancreatic β cell ATP-sensitive K+ (KATP) channel and on …
Therapeutic Targeting of Potassium Channels
N Gamper, D Huang, J Qi, L Dong, H Zhang - Ion Channels as Targets in …, 2024 - Springer
Potassium (K+) channels are the largest group of ion channels in mammals. The immediate
function of these channels is electrogenic transport of K+ ions across the cellular …
function of these channels is electrogenic transport of K+ ions across the cellular …
Iptakalim rescues human pulmonary artery endothelial cells from hypoxia-induced nitric oxide system dysfunction
F Zong, XR Zuo, Q Wang… - Experimental and …, 2012 - spandidos-publications.com
The aim of this study was to assess whether hypoxia inhibits endothelial nitric oxide
synthase (eNOS) activity and nitric oxide (NO) production, and whether iptakalim may …
synthase (eNOS) activity and nitric oxide (NO) production, and whether iptakalim may …
Proteomic analysis of the effect of iptakalim on human pulmonary arterial smooth muscle cell proliferation
M Yang, Z Liu, S Zhang, Y Jing, S Zhang… - Acta Pharmacologica …, 2009 - nature.com
Aim: To investigate the anti-proliferative effect of iptakalim (Ipt), a newly selective K ATP
channel opener, in endothelin-1 (ET-1)-induced human pulmonary arterial smooth muscle …
channel opener, in endothelin-1 (ET-1)-induced human pulmonary arterial smooth muscle …