Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment

RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin

TA Pollak, BR Lennox, S Müller, ME Benros… - The Lancet …, 2020 - thelancet.com
There is increasing recognition in the neurological and psychiatric literature of patients with
so-called isolated psychotic presentations (ie, with no, or minimal, neurological features) …

[HTML][HTML] Clinical guidance on the identification and management of treatment-resistant schizophrenia

JM Kane, O Agid, ML Baldwin… - The Journal of …, 2019 - legacy.psychiatrist.com
Treatment-resistant schizophrenia (TRS) occurs in approximately 30% of individuals
diagnosed with schizophrenia. The identification and management of TRS in clinical …

Immune system abnormalities in schizophrenia: an integrative view and translational perspectives

EA Ermakov, MM Melamud, VN Buneva… - Frontiers in …, 2022 - frontiersin.org
The immune system is generally known to be the primary defense mechanism against
pathogens. Any pathological conditions are reflected in anomalies in the immune system …

The origin of NMDA receptor hypofunction in schizophrenia

K Nakazawa, K Sapkota - Pharmacology & therapeutics, 2020 - Elsevier
Abstract N-methyl-d-aspartate (NMDA) receptor (NMDAR) hypofunction plays a key role in
pathophysiology of schizophrenia. Since NMDAR hypofunction has also been reported in …

Glutamatergic dysfunction in Schizophrenia

AO Kruse, JR Bustillo - Translational Psychiatry, 2022 - nature.com
The NMDA-R hypofunction model of schizophrenia started with the clinical observation of
the precipitation of psychotic symptoms in patients with schizophrenia exposed to PCP or …

Schizophrenia and influenza at the centenary of the 1918-1919 Spanish influenza pandemic: mechanisms of psychosis risk

AP Kępińska, CO Iyegbe, AC Vernon, R Yolken… - Frontiers in …, 2020 - frontiersin.org
Associations between influenza infection and psychosis have been reported since the
eighteenth century, with acute “psychoses of influenza” documented during multiple …

Autoimmune encephalopathies

F Leypoldt, T Armangue… - Annals of the New York …, 2015 - Wiley Online Library
Over the past 10 years, the continual discovery of novel forms of encephalitis associated
with antibodies to cell‐surface or synaptic proteins has changed the paradigms for …

The blood–brain barrier in psychosis

TA Pollak, S Drndarski, JM Stone, AS David… - The Lancet …, 2018 - thelancet.com
Blood–brain barrier pathology is recognised as a central factor in the development of many
neurological disorders, but much less is known about the role of the blood–brain barrier in …

Association of depression and anxiety disorders with autoimmune thyroiditis: a systematic review and meta-analysis

EM Siegmann, HHO Müller, C Luecke… - JAMA …, 2018 - jamanetwork.com
Importance With a prevalence of 4% to 13% in the United States, autoimmune thyroiditis
(AIT) is a major health problem. Besides somatic complications, patients with AIT can also …