Current methods to analyze lysosome morphology, positioning, motility and function
Since the discovery of lysosomes more than 70 years ago, much has been learned about
the functions of these organelles. Lysosomes were regarded as exclusively degradative …
the functions of these organelles. Lysosomes were regarded as exclusively degradative …
Plant glycosides and glycosidases: a treasure-trove for therapeutics
K Kytidou, M Artola, HS Overkleeft… - Frontiers in plant …, 2020 - frontiersin.org
Plants contain numerous glycoconjugates that are metabolized by specific
glucosyltransferases and hydrolyzed by specific glycosidases, some also catalyzing …
glucosyltransferases and hydrolyzed by specific glycosidases, some also catalyzing …
The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection
Lysosomes are key degradative compartments of the cell. Transport to lysosomes relies on
GlcNAc-1-phosphotransferase–mediated tagging of soluble enzymes with mannose 6 …
GlcNAc-1-phosphotransferase–mediated tagging of soluble enzymes with mannose 6 …
Neuronal soma-derived degradative lysosomes are continuously delivered to distal axons to maintain local degradation capacity
Neurons face the challenge of maintaining cellular homeostasis through lysosomal
degradation. While enzymatically active degradative lysosomes are enriched in the soma …
degradation. While enzymatically active degradative lysosomes are enriched in the soma …
Activity-based protein profiling: Recent advances in medicinal chemistry
H Deng, Q Lei, Y Wu, Y He, W Li - European journal of medicinal chemistry, 2020 - Elsevier
Activity-based protein profiling (ABPP) has become an emerging chemical proteomic
approach to illustrate the interaction mechanisms between compounds and proteins. This …
approach to illustrate the interaction mechanisms between compounds and proteins. This …
Rational Design of Mechanism-Based Inhibitors and Activity-Based Probes for the Identification of Retaining α-l-Arabinofuranosidases
Identifying and characterizing the enzymes responsible for an observed activity within a
complex eukaryotic catabolic system remains one of the most significant challenges in the …
complex eukaryotic catabolic system remains one of the most significant challenges in the …
Glucocerebrosidase: functions in and beyond the lysosome
DEC Boer, J van Smeden, JA Bouwstra… - Journal of clinical …, 2020 - mdpi.com
Glucocerebrosidase (GCase) is a retaining β-glucosidase with acid pH optimum
metabolizing the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose …
metabolizing the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose …
Animal Models for the Study of Gaucher Disease
O Cabasso, A Kuppuramalingam, L Lelieveld… - International Journal of …, 2023 - mdpi.com
In Gaucher disease (GD), a relatively common sphingolipidosis, the mutant lysosomal
enzyme acid β-glucocerebrosidase (GCase), encoded by the GBA1 gene, fails to properly …
enzyme acid β-glucocerebrosidase (GCase), encoded by the GBA1 gene, fails to properly …
Selective labelling of GBA2 in cells with fluorescent β-d-arabinofuranosyl cyclitol aziridines
Q Su, M Louwerse, RF Lammers, E Maurits… - Chemical …, 2024 - pubs.rsc.org
GBA2, the non-lysosomal β-glucosylceramidase, is an enzyme involved in glucosylceramide
metabolism. Pharmacological inhibition of GBA2 by N-alkyl iminosugars is well tolerated …
metabolism. Pharmacological inhibition of GBA2 by N-alkyl iminosugars is well tolerated …
Functionalized cyclophellitols are selective glucocerebrosidase inhibitors and induce a bona fide neuropathic Gaucher model in zebrafish
Gaucher disease is caused by inherited deficiency in glucocerebrosidase (GBA, a retaining
β-glucosidase), and deficiency in GBA constitutes the largest known genetic risk factor for …
β-glucosidase), and deficiency in GBA constitutes the largest known genetic risk factor for …