Aging is a multifaceted and complicated process, manifested by a decline of normal
physiological functions across tissues and organs, leading to overt frailty, mortality, and …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Oxidative stress is the increase in cellular oxidant concentration in comparison to antioxidant
titer. Toxic insults and many other diseased conditions are mediated through the formation of …

Rationale: Vascular smooth muscle cell (VSMC) senescence promotes atherosclerosis and
features of plaque instability, in part, through lipid-mediated oxidative DNA damage and …

Background Cataracts are the main cause of reversible blindness worldwide. The ageing of
the lens caused by ultraviolet B (UVB) radiation is mostly related to oxidative stress (OS) …

Sirtuins are NAD+-dependent deacetylase and deacylase enzymes that control important
cellular processes, including DNA damage repair, cellular metabolism, mitochondrial …

Most deaths from the COVID-19 pandemic are due to acute respiratory distress syndrome
(ARDS)-related respiratory failure. Cytokine storms and oxidative stress are the major …

Rationale: Doxorubicin is one of the most potent antitumor agents available; however, its
clinical use is restricted because it poses a risk of severe cardiotoxicity. Previous work has …

The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …

Sirtuin 6 (SIRT6) has been in the spotlight of aging research because progeroid phenotypes
are associated with SIRT6 deficiency. SIRT6 has multiple molecular functions, including …