The interplay between chromatin, transcription factors and genes generates complex
regulatory circuits that can be represented as gene regulatory networks (GRNs). The study …

Metabolic engineering is the enabling science of development of efficient cell factories for
the production of fuels, chemicals, pharmaceuticals, and food ingredients through microbial …

We have analyzed the maize leaf transcriptome using Illumina sequencing. We mapped
more than 120 million reads to define gene structure and alternative splicing events and to …

The aim of this article was to generate a framework of bio-based economy by an effective
utilization of biomass from the perspectives of agriculture for developing potential end bio …

Natural small compounds comprise most cellular molecules and bind proteins as substrates,
products, cofactors, and ligands. However, a large-scale investigation of in vivo protein …

Saccharomyces cerevisiae is commonly used as a microbial cell factory to produce high-
value compounds or bulk chemicals due to its genetic operability and suitable intracellular …

The idea that multi-scale dynamic complex systems formed by interacting macromolecules
and metabolites, cells, organs and organisms underlie some of the most fundamental …

Over the past decade, the development and application of chemical genomic assays using
the model organism Saccharomyces cerevisiae has provided powerful methods to identify …

Abstract Model organisms have played a huge part in the history of studies of human genetic
disease, both in identifying disease genes and characterizing their normal and abnormal …

Gene regulatory networks (GRNs) are interpretable graph models encompassing the
regulatory interactions between transcription factors (TFs) and their downstream target …