Computer aided drug design: success and limitations

M Hassan Baig, K Ahmad, S Roy… - Current …, 2016 - ingentaconnect.com
Over the last few decades, computer-aided drug design has emerged as a powerful
technique playing a crucial role in the development of new drug molecules. Structure-based …

Isolated compounds from natural products with potential antidiabetic activity-a systematic review

ACM Munhoz, TS Frode - Current diabetes reviews, 2018 - benthamdirect.com
Background: Worldwide, Type 2 diabetes has become a growing health problem. While
many research articles in the field of ethnopharmacology have focused on the antidiabetic …

Xanthone glucosides: Isolation, bioactivity and synthesis

Q Huang, Y Wang, H Wu, M Yuan, C Zheng, H Xu - Molecules, 2021 - mdpi.com
Xanthones are secondary metabolites found in plants, fungi, lichens, and bacteria from a
variety of families and genera, with the majority found in the Gentianaceae, Polygalaceae …

The role of traditional Chinese medicine in the regulation of oxidative stress in treating coronary heart disease

X Yang, T He, S Han, X Zhang, Y Sun… - Oxidative Medicine …, 2019 - Wiley Online Library
Oxidative stress has been closely related with coronary artery disease. In coronary heart
disease (CHD), an excess of reactive oxygen species (ROS) production generates …

Assessment of In Vivo Antidiabetic Properties of Umbelliferone and Lupeol Constituents of Banana (Musa sp. var. Nanjangud Rasa Bale) Flower in Hyperglycaemic …

R Ramu, P S. Shirahatti, F Zameer… - PLoS …, 2016 - journals.plos.org
Banana is an extensively cultivated plant worldwide, mainly for its fruit, while its ancillary
product, the banana flower is consumed as a vegetable and is highly recommended for …

Elicitation enhances swerchirin and 1, 2, 5, 6-tetrahydroxyxanthone production in hairy root cultures of Swertia chirayita (Roxb.) H. Karst.

G Mahendran, N Verma, M Singh, K Shanker… - Industrial Crops and …, 2022 - Elsevier
Abstract Swertia chirayita (Roxb.) H. Karst. is a medicinal herb used in traditional medicines.
Scientific authentications of its multiple health benefits against several diseases have …

Umbelliferone attenuates diabetic cardiomyopathy by suppression of JAK/STAT signaling pathway through amelioration of oxidative stress and inflammation in rats

SM Khadrawy, RA El Sayed - Journal of Biochemical and …, 2023 - Wiley Online Library
Abstract Umbelliferone (UMB), 7‐hydroxycoumarin, is a naturally occurring coumarin
derivative that has a plethora of biological and therapeutic activities. The focus of this …

[HTML][HTML] Effects of Centella asiatica on skeletal muscle structure and key enzymes of glucose and glycogen metabolism in type 2 diabetic rats

AB Oyenihi, SOP Langa, S Mukaratirwa… - Biomedicine & …, 2019 - Elsevier
Background Dysregulation of glucose and glycogen metabolism are crucial mechanisms
implicated in type 2 diabetes mellitus (T2DM). Centella asiatica (L.) Urban (Apiaceae) has …

Schiff bases of pioglitazone provide better antidiabetic and potent antioxidant effect in a streptozotocin–nicotinamide-induced diabetic rodent model

HR Afzal, NH Khan, K Sultana, A Mobashar, A Lareb… - ACS …, 2021 - ACS Publications
Pioglitazone is a Food and Drug Administration-approved thiazolidinedione (TZD) derivative
and peroxisome proliferator-activated receptor gamma (PPARγ) agonist and used for the …

[HTML][HTML] α-Mangostin mediated pharmacological modulation of hepatic carbohydrate metabolism in diabetes induced Wistar rat

V Kumar, PC Bhatt, G Kaithwas, M Rashid… - Beni-suef university …, 2016 - Elsevier
Garcinia mangostana L.(Fruit) has been commonly used as folklore drug in the treatment of
various types of diseases. The present experiment was designed to evaluate the potential …