Animals transmit not only DNA but also other molecules, such as RNA, proteins and
metabolites, to their progeny via gametes. It is currently unclear to what extent these …

Argonaute (AGO) proteins associate with small RNAs to direct their effector function on
complementary transcripts. The nematode Caenorhabditis elegans contains an expanded …

Non-membrane-bound organelles such as nucleoli, processing bodies, Cajal bodies and
germ granules form by the spontaneous self-assembly of specific proteins and RNAs. How …

P granules are RNA/protein condensates in the germline of Caenorhabditis elegans.
Genetic analyses have begun to identify the proteins that regulate P granule assembly in the …

Inherited epigenetic information has been observed to regulate a variety of complex
organismal phenotypes across diverse taxa of life. This continually expanding body of …

A rapidly growing body of literature in several organisms suggests that environmentally-
induced adaptive changes in phenotype can be transmitted across multiple generations …

In recent years it has become evident that RNA interference-related mechanisms can
mediate the deposition and transgenerational inheritance of specific chromatin modifications …

The transparency of Caenorhabditis elegans provides a unique window to observe and
study the function of germ granules. Germ granules are specialized ribonucleoprotein (RNP) …

PIWI-interacting RNAs (piRNAs) promote fertility in many animals. However, whether this is
due to their conserved role in repressing repetitive elements (REs) remains unclear. Here …

Germ granules are membrane-less organelles essential for small RNA biogenesis and
germline development. Among the conserved properties of germ granules is their …