The remarkable success of immune checkpoint inhibitors demonstrates the potential of
tumour-specific CD8+ T cells to prevent and treat cancer. Although the number of lives …

Recent proteogenomic studies revealed extensive translation outside of annotated protein
coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non …

Upstream open reading frames (uORFs) are ubiquitous repressive genetic elements in
vertebrate mRNAs. While much is known about the regulation of individual genes by their …

Gene expression universally relies on protein synthesis, where ribosomes recognize and
decode the messenger RNA template by cycling through translation initiation, elongation …

Ribosome profiling is a powerful technique used to study translation at the genome-wide
level, generating unique information concerning ribosome positions along RNAs. Optimal …

Abstract The development of Ribosome Profiling (RiboSeq) has revolutionized functional
genomics. RiboSeq is based on capturing and sequencing of the mRNA fragments enclosed …

Translation is principally regulated at the initiation stage. The development of the translation
initiation (TI) sequencing (TI-seq) technique has enabled the global mapping of TIs and …

Eukaryotic ribosome and cap-dependent translation are attractive targets in the antitumor,
antiviral, anti-inflammatory, and antiparasitic therapies. Currently, a broad array of small …

PTEN is a critical tumour suppressor that is frequently mutated in human cancer. We have
previously identified a CUG initiated PTEN isoform designated PTENα, which functions in …

A large body of evidence indicates that genome annotation pipelines have biased our view
of coding sequences because they generally undersample small proteins and peptides. The …