Neuroinflammation is a physiological protective response in the context of infection and
injury. However, neuroinflammation, especially if chronic, may also drive …

Neuroactive steroids synthesized in neuronal tissue, referred to as neurosteroids, are
implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids …

When steroids, such as pregnenolone, progesterone and oestrogen, are synthesised de
novo in neural tissues, they are more specifically referred to as neurosteroids. These …

Neuroactive steroids include synthetic steroidal compounds and endogenous steroids,
produced by endocrine glands (hormonal steroids) or the nervous tissue (neurosteroids) …

Neurosteroids are a relatively new class of neuroactive compounds brought to prominence
in the past 2 decades. Despite knowing of their presence in the nervous system of various …

The neurosteroid pregnenolone and its sulfated derivative enhance learning and memory in
rodents. Pregnenolone sulfate also positively modulates NMDA receptors and could thus …

Neurons and glia in the central nervous system express the necessary enzymes for the
synthesis of neurosteroids that are produced in concentrations high enough to exert …

Emerging preclinical and clinical evidence suggests that pregnenolone may be a promising
novel therapeutic candidate in schizophrenia. Pregnenolone is a neurosteroid with …

Dehydroepiandrosterone (DHEA) is the most abundant circulating steroid hormone in
humans, produced by the adrenals, the gonads and the brain. DHEA was previously shown …

Neuroactive steroids can be synthetic or endogenous molecules produced by neuronal and
glial cells and peripheral glands. Examples include estrogens, testosterone, progesterone …