[HTML][HTML] Human papillomavirus vaccine against cervical cancer: Opportunity and challenge

R Wang, W Pan, L Jin, W Huang, Y Li, D Wu, C Gao… - Cancer letters, 2020 - Elsevier
Cervical cancer is one of the most common cancers threatening women's health, and the
persistent infection of high-risk human papillomavirus (HPV) is closely related to the …

Clinician's guide to human papillomavirus immunology: knowns and unknowns

MH Einstein, JT Schiller, RP Viscidi… - The Lancet infectious …, 2009 - thelancet.com
Oncogenic human papillomavirus (HPV) is a common genital infection that has the potential
to develop into cervical cancer in some women. This Review summarises current knowledge …

CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer

FL Komdeur, TM Prins, S van de Wall, A Plat… - …, 2017 - Taylor & Francis
Human papilloma virus (HPV)-induced cervical cancer constitutively expresses viral E6/E7
oncoproteins and is an excellent target for T cell-based immunotherapy. However, not all …

Phase II trial of imiquimod and HPV therapeutic vaccination in patients with vulval intraepithelial neoplasia

S Daayana, E Elkord, U Winters, M Pawlita… - British journal of …, 2010 - nature.com
Background: Vulval intraepithelial neoplasia (VIN) is a premalignant condition, which is
frequently associated with type HPV16 infection, and multifocal disease has high rates of …

Therapeutic HPV vaccines

G Hancock, K Hellner, L Dorrell - … practice & research Clinical obstetrics & …, 2018 - Elsevier
Highlights•Current prophylactic vaccines protect only against infection with high risk types
HPV16 and 18.•Several new platform technologies are being applied to the development of …

Current status and future directions for the development of human papillomavirus vaccines

R Wang, H Huang, C Yu, X Li, Y Wang… - Frontiers in …, 2024 - frontiersin.org
The development of human papillomavirus (HPV) vaccines has made substantive progress,
as represented by the approval of five prophylactic vaccines since 2006. Generally, the …

HPV infection: immunological aspects and their utility in future therapy

E Deligeoroglou, A Giannouli… - … in obstetrics and …, 2013 - Wiley Online Library
High prevalence and mortality rates of cervical cancer create an imperative need to clarify
the uniqueness of HPV (Human Papillomavirus) infection, which serves as the key causative …

The interplay between HPV and host immunity in head and neck squamous cell carcinoma

AS Andersen, AS Koldjær Sølling… - … journal of cancer, 2014 - Wiley Online Library
Persistent infection with human papillomavirus (HPV) type 16 is a major risk factor for the
development of head and neck squamous cell carcinoma (HNSCC), in particular …

Current therapeutic vaccination and immunotherapy strategies for HPV-related diseases

JG Skeate, AW Woodham, MH Einstein… - Human vaccines & …, 2016 - Taylor & Francis
Carcinomas of the anogenital tract, in particular cervical cancer, remains one of the most
common cancers in women, and represent the most frequent gynecological malignancies …

Modeling the long-term antibody response of a human papillomavirus (HPV) virus-like particle (VLP) type 16 prophylactic vaccine

C Fraser, JE Tomassini, L Xi, G Golm, M Watson… - Vaccine, 2007 - Elsevier
The duration over which antibody responses persist following HPV vaccination is unknown.
To estimate the longevity of responses induced by HPV-16 vaccination, two models were …