Atherosclerosis develops due to lipid accumulation in the arterial wall and sclerosis as result
of increased hyperlipidemia, oxidative stress, lipid oxidation, and protein oxidation …

Uptake of low-density lipoprotein (LDL) particles by macrophages represents a key step in
the development of atherosclerotic plaques, leading to the foam cell formation. Chemical …

Human PON1 is a HDL-associated lipolactonase capable of preventing LDL and cell
membrane oxidation and is therefore considered to be atheroprotective. PON1 contributes to …

The clinical events resulting from atherosclerosis are directly related to the oxidation of lipids
in LDLs that become trapped in the extracellular matrix of the subendothelial space. These …

HDL levels are inversely related to the risk of developing atherosclerosis. In serum,
paraoxonase (PON) is associated with HDL, and was shown to inhibit LDL oxidation …

We have investigated the Cu 2+ induced generation of lipid peroxides in low density
lipoprotein (LDL) incubated with high density lipoprotein (HDL) and with purified …

Our group has previously demonstrated that oxidized phospholipids in mildly oxidized LDL
(MM-LDL) produced by oxidation with lipoxygenase, iron, or cocultures of artery wall cells …

Serum paraoxonase (PON1) is an esterase that is associated with high-density lipoproteins
(HDLs) in the plasma; it is involved in the detoxification of organophosphate insecticides …

There is considerable evidence that the antioxidant activity of high density lipoprotein (HDL)
is largely due to the paraoxonase-1 (PON1) located on it. Experiments with transgenic PON1 …

We previously reported that high density lipoprotein (HDL) protects against the oxidative
modification of low density lipoprotein (LDL) induced by artery wall cells causing these cells …