Microbial transformations of human bile acids

DV Guzior, RA Quinn - Microbiome, 2021 - Springer
Bile acids play key roles in gut metabolism, cell signaling, and microbiome composition.
While the liver is responsible for the production of primary bile acids, microbes in the gut …

The art of measuring steroids: principles and practice of current hormonal steroid analysis

SA Wudy, G Schuler, A Sánchez-Guijo… - The Journal of steroid …, 2018 - Elsevier
Steroids are small and highly important structural or signalling molecules in living organisms
and their metabolism is complex. Due to the multiplicity of enzymes involved there are many …

The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk

DD Wang, LH Nguyen, Y Li, Y Yan, W Ma, E Rinott… - Nature medicine, 2021 - nature.com
To address how the microbiome might modify the interaction between diet and
cardiometabolic health, we analyzed longitudinal microbiome data from 307 male …

Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome

ACD Machado, SD Brown, A Lingaraju, V Sivaganesh… - Cell reports, 2022 - cell.com
Compositional oscillations of the gut microbiome are essential for normal peripheral
circadian rhythms, both of which are disrupted in diet-induced obesity (DIO). Although time …

Low dietary fiber intake increases Collinsella abundance in the gut microbiota of overweight and obese pregnant women

LF Gomez-Arango, HL Barrett, SA Wilkinson… - Gut …, 2018 - Taylor & Francis
The gut microbiota contributes to the regulation of glucose metabolism in pregnancy.
Abundance of the genus Collinsella is positively correlated with circulating insulin; however …

Intestinal transgene delivery with native E. coli chassis allows persistent physiological changes

BJ Russell, SD Brown, N Siguenza, I Mai, AR Saran… - Cell, 2022 - cell.com
Live bacterial therapeutics (LBTs) could reverse diseases by engrafting in the gut and
providing persistent beneficial functions in the host. However, attempts to functionally …

The gut microbiota drives the impact of bile acids and fat source in diet on mouse metabolism

S Just, S Mondot, J Ecker, K Wegner, E Rath, L Gau… - Microbiome, 2018 - Springer
Background As the gut microbiota contributes to metabolic health, it is important to
determine specific diet-microbiota interactions that influence host metabolism. Bile acids and …

Dominant bacterial phyla from the human gut show widespread ability to transform and conjugate bile acids

LN Lucas, K Barrett, RL Kerby, Q Zhang, LE Cattaneo… - …, 2021 - Am Soc Microbiol
Gut bacteria influence human physiology by chemically modifying host-synthesized primary
bile acids. These modified bile acids, known as secondary bile acids, can act as signaling …

Cigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites

X Bai, H Wei, W Liu, OO Coker, H Gou, C Liu, L Zhao… - Gut, 2022 - gut.bmj.com
Objective Cigarette smoking is a major risk factor for colorectal cancer (CRC). We aimed to
investigate whether cigarette smoke promotes CRC by altering the gut microbiota and …

The core human microbiome: does it exist and how can we find it? A critical review of the concept

I Sharon, NM Quijada, E Pasolli, M Fabbrini, F Vitali… - Nutrients, 2022 - mdpi.com
The core microbiome, which refers to a set of consistent microbial features across
populations, is of major interest in microbiome research and has been addressed by …