High allelic diversity in Arabidopsis NLRs is associated with distinct genomic features

CA Sutherland, DM Prigozhin, JG Monroe… - EMBO …, 2024 - embopress.org
Plants rely on Nucleotide-binding, Leucine-rich repeat Receptors (NLRs) for pathogen
recognition. Highly variable NLRs (hvNLRs) show remarkable intraspecies diversity, while …

Deciphering the role of FOXP4 in long COVID: exploring genetic associations, evolutionary conservation, and drug identification through bioinformatics analysis

MK Gupta, G Gouda, R Vadde - Functional & Integrative Genomics, 2024 - Springer
Long COVID (LC) refers to a condition characterized by a variety of lingering symptoms that
persist for more than 4 to 12 weeks following the initial acute SARS-CoV-2 infection. Recent …

H3K4me1 recruits DNA repair proteins in plants

D Quiroz, S Oya, D Lopez-Mateos, K Zhao… - The Plant …, 2024 - academic.oup.com
DNA repair proteins can be recruited by their histone reader domains to specific epigenomic
features, with consequences on intragenomic mutation rate variation. Here, we investigated …

[HTML][HTML] High intraspecies allelic diversity in Arabidopsis NLR immune receptors is associated with distinct genomic and epigenomic features

CA Sutherland, DM Prigozhin, JG Monroe… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Plants rely on Nucleotide-binding, Leucine-rich repeat Receptors (NLRs) for pathogen
recognition. Highly variable NLRs (hvNLRs) show remarkable intraspecies diversity, while …

Are mutations random?

G Monroe - 2023 - academic.oup.com
The idea that “mutations are random” is ubiquitous in evolutionary biology. But do
evolutionary biologists agree on what it means? What does a historical account teach us …

Convergent evolution of epigenome recruited DNA repair across the Tree of Life

JG Monroe, C Lee, D Quiroz, M Lensink, S Oya… - bioRxiv, 2024 - biorxiv.org
Mutations fuel evolution while also causing diseases like cancer. Epigenome-targeted DNA
repair can help organisms protect important genomic regions from mutation. However, the …