The RIPK1-RIPK3 necrosome is an amyloid signaling complex that initiates TNF-induced
necroptosis, serving in human immune defense, cancer, and neurodegenerative diseases …

Transactive response DNA-binding protein 43 (TDP-43) performs multiple tasks in mRNA
processing, transport, and translational regulation, but it also forms aggregates implicated in …

In the Drosophila immune response, bacterial derived diaminopimelic acid-type
peptidoglycan binds the receptors PGRP-LC and PGRP-LE, which through interaction with …

Hydrogen bond cooperativity (HBC) plays an important role in stabilizing protein assemblies
built by α-helices and β-sheets, the most common secondary structures. However, whether …

TDP-43 is an essential RNA-binding protein forming aggregates in almost all cases of
sporadic amyotrophic lateral sclerosis (ALS) and many cases of frontotemporal lobar …

With the rapid development of the market economy, there are more and more projects in the
financial industry, and their complexity and technical requirements are getting higher and …

The pathogenesis of Parkinson's disease is closely associated with the aggregation of the α-
synuclein protein. Several familial mutants have been identified and shown to affect the …

Prion transmission between species is governed in part by primary sequence similarity
between the infectious prion aggregate, PrP Sc, and the cellular prion protein of the host …

Enzymes and structural proteins dominated thinking about protein structure and function for
most of the twentieth century. In recent decades, however, we have begun to appreciate the …

Abstract Transactive Response DNA-Binding Protein of 43 kDa (TDP-43) is an essential
human protein implicated in Amyotrophic Lateral Sclerosis (ALS) and common dementias …