The brain is astonishing in its complexity and capacity for change. This has fascinated
scientists for more than a century, filling the pages of this journal for the past 25 years. But a …

Integrins are a large family of extracellular matrix (ECM) receptors. In the developing and
adult brain, many integrins are present at high levels at synapses. The tetrapartite structure …

Brain development, sensory information processing, and learning and memory processes
depend on Hebbian forms of synaptic plasticity, and on the remodeling and pruning of …

Although many details remain still elusive, it became increasingly evident in recent years
that mechanosensing of microenvironmental biophysical cues and subsequent …

The formation of correct synaptic structures and neuronal connections is paramount for
normal brain development and a functioning adult brain. The integrin family of cell adhesion …

Integrins are cell surface receptors that form the link between extracellular matrix molecules
of the cell environment and internal cell signalling and the cytoskeleton. They are involved in …

Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix
(ECM) molecules that compose or interact with PNNs, in the pathophysiology of several …

Astrocytes contribute to the formation, function, and plasticity of synapses. Their processes
enwrap the neuronal components of the tripartite synapse, and due to this close interaction …

Synaptic plasticity mechanisms are usually discussed in terms of changes in synaptic
strength. The capacity of excitatory synapses to rapidly modify the membrane expression of …

Alzheimer's disease (AD) is an irreversible brain disorder characterized by progressive
cognitive decline and neurodegeneration of brain regions that are crucial for learning and …