40 years after the registration of acyclovir: do we need new anti-herpetic drugs?

A Majewska, B Mlynarczyk-Bonikowska - International journal of …, 2022 - mdpi.com
Herpes simplex virus types 1 and 2 HSV1 and 2, namely varicella-zoster VZV and
cytomegalovirus CMV, are among the most common pathogens worldwide. They remain in …

Prevention strategies for sexually transmitted infections, HIV, and viral hepatitis in Europe

D Gökengin, T Noori, A Alemany… - The Lancet Regional …, 2023 - thelancet.com
The current prevention efforts for STIs, HIV and viral hepatitis in the WHO European Region,
especially in the Central and Eastern subregions, are hindered by healthcare disparities …

An HSV-2 nucleoside-modified mRNA genital herpes vaccine containing glycoproteins gC, gD, and gE protects mice against HSV-1 genital lesions and latent infection

KP Egan, LM Hook, A Naughton, N Pardi… - PLoS …, 2020 - journals.plos.org
HSV-1 causes 50% of first-time genital herpes infections in resource-rich countries and
affects 190 million people worldwide. A prophylactic herpes vaccine is needed to protect …

Trivalent nucleoside-modified mRNA vaccine yields durable memory B cell protection against genital herpes in preclinical models

S Awasthi, JJ Knox, A Desmond… - The Journal of …, 2021 - Am Soc Clin Investig
Nucleoside-modified mRNA vaccines have gained global attention because of COVID-19.
We evaluated a similar vaccine approach for preventing a chronic, latent genital infection …

Neonatal herpes simplex virus infection: From the maternal infection to the child outcome

DU De Rose, S Bompard, C Maddaloni… - Journal of Medical …, 2023 - Wiley Online Library
This review examines the recent literature on the management of herpes simplex virus
(HSV) infections in neonates. We summarized the three clinical categories of maternal HSV …

Therapeutic vaccines for herpesviruses

JI Cohen - The Journal of Clinical Investigation, 2024 - Am Soc Clin Investig
Herpesviruses establish latent infections, and most reactivate frequently, resulting in
symptoms and virus shedding in healthy individuals. In immunocompromised patients …

The Interplay of Genital Herpes with Cellular Processes: A Pathogenesis and Therapeutic Perspective

H Borase, D Shukla - Viruses, 2023 - mdpi.com
Genital herpes, primarily caused by herpes simplex virus-2 (HSV-2), remains a pressing
global health concern. Its remarkable ability to intertwine with cellular processes, from …

Immune response to herpes simplex virus infection and vaccine development

AC Ike, CJ Onu, CM Ononugbo, EE Reward, SO Muo - Vaccines, 2020 - mdpi.com
Herpes simplex virus (HSV) infections are among the most common viral infections and
usually last for a lifetime. The virus can potentially be controlled with vaccines since humans …

Monoclonal antibody therapy of herpes simplex virus: An opportunity to decrease congenital and perinatal infections

IM Backes, DA Leib, ME Ackerman - Frontiers in Immunology, 2022 - frontiersin.org
The fetal/neonatal period represents both a unique window of opportunity for interventions
as well as vulnerability to a number of viral infections. While Herpesviruses such as herpes …

A review of HSV pathogenesis, vaccine development, and advanced applications

L Bai, J Xu, L Zeng, L Zhang, F Zhou - Molecular Biomedicine, 2024 - Springer
Herpes simplex virus (HSV), an epidemic human pathogen threatening global public health,
gains notoriety for its complex pathogenesis that encompasses lytic infection of mucosal …