Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials

CM Zipser, JJ Cragg, JD Guest, MG Fehlings… - The Lancet …, 2022 - thelancet.com
Spinal cord injury is a severely disabling neurological condition leading to impaired mobility,
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …

Acute traumatic spinal cord injury

I Eli, DP Lerner, Z Ghogawala - Neurologic clinics, 2021 - neurologic.theclinics.com
Acute traumatic spinal cord injury (SCI) is typically associated with devastating outcomes.
The injury to the spinal cord results in damage to motor, sensory, and autonomic functions of …

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

Y Wang, J Hu, S Wu, JS Fleishman, Y Li, Y Xu… - … and Targeted Therapy, 2023 - nature.com
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging

G David, S Mohammadi, AR Martin… - Nature Reviews …, 2019 - nature.com
Pathophysiological changes in the spinal cord white and grey matter resulting from injury
can be observed with MRI techniques. These techniques provide sensitive markers of …

A new framework for investigating the biological basis of degenerative cervical myelopathy [AO Spine RECODE-DCM Research Priority Number 5]: mechanical stress …

BM Davies, O Mowforth, AA Gharooni… - Global Spine …, 2022 - journals.sagepub.com
Study Design Literature Review (Narrative) Objective To propose a new framework, to
support the investigation and understanding of the pathobiology of DCM, AO Spine …

Emerging nanotechnology for Alzheimer's disease: From detection to treatment

N Song, S Sun, K Chen, Y Wang, H Wang… - Journal of Controlled …, 2023 - Elsevier
Abstract Alzheimer's disease (AD), one of the most common chronic neurodegenerative
diseases, is characterized by memory impairment, synaptic dysfunction, and character …

Is graphene shortening the path toward spinal cord regeneration?

AF Girão, MC Serrano, A Completo, PAAP Marques - ACS nano, 2022 - ACS Publications
Along with the development of the next generation of biomedical platforms, the inclusion of
graphene-based materials (GBMs) into therapeutics for spinal cord injury (SCI) has potential …

Multiparameter mapping of relaxation (R1, R2*), proton density and magnetization transfer saturation at 3 T: A multicenter dual‐vendor reproducibility and repeatability …

T Leutritz, M Seif, G Helms, RS Samson… - Human brain …, 2020 - Wiley Online Library
Multicenter clinical and quantitative magnetic resonance imaging (qMRI) studies require a
high degree of reproducibility across different sites and scanner manufacturers, as well as …

How can clinical safety and efficacy concerns in stem cell therapy for spinal cord injury be overcome?

N Hejrati, R Wong, M Khazaei… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Spinal cord injury (SCI) can lead to severe neurological dysfunction. Despite
scientific and medical advances, clinically effective regenerative therapies including stem …

Imaging and electrophysiology for degenerative cervical myelopathy [AO Spine RECODE-DCM Research Priority Number 9]

AR Martin, L Tetreault, A Nouri, A Curt… - Global spine …, 2022 - journals.sagepub.com
Study Design Narrative review. Objective The current review aimed to describe the role of
existing techniques and emerging methods of imaging and electrophysiology for the …