Simple Summary The cytoskeleton is a network of protein fibres within cells that provide
structure and support intracellular transport. Focal adhesions are protein complexes …

Integrins can alter cellular behavior through the recruitment and activation of signaling
proteins such as non-receptor tyrosine kinases including focal adhesion kinase (FAK) and c …

FAK is a tyrosine kinase overexpressed in cancer cells and plays an important role in the
progression of tumors to a malignant phenotype. Except for its typical role as a cytoplasmic …

Nonalcoholic steatohepatitis (NASH), a common clinical disease, is becoming a leading
cause of hepatocellular carcinoma (HCC). Dual specificity phosphatase 22 (DUSP22, also …

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase with key roles in the
regulation of cell adhesion migration, proliferation and survival. In cancer FAK is a major …

Focal adhesion kinase (FAK) is a scaffold and tyrosine kinase protein that binds to itself and
cellular partners through its four-point-one, ezrin, radixin, moesin (FERM) domain. Recent …

Focal adhesion kinase (FAK) is a protein tyrosine kinase that regulates cellular adhesion,
motility, proliferation and survival in various types of cells. Interestingly, FAK is activated …

Appropriate tyrosine kinase signaling depends on coordinated sequential coupling of
protein-protein interactions with catalytic activation. Focal adhesion kinase (FAK) integrates …

Members of the ezrin–radixin–moesin (ERM) family of proteins are involved in multiple
aspects of cell migration by acting both as crosslinkers between the membrane, receptors …

Focal adhesion kinase (FAK) is considered as a pivotal intracellular non-receptor tyrosine
kinase, and has garnered significant attention as a promising target for anticancer drug …