High-throughput and single-cell T cell receptor sequencing technologies
JA Pai, AT Satpathy - Nature methods, 2021 - nature.com
T cells express T cell receptors (TCRs) composed of somatically recombined TCRα and
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …
Next-generation regulatory T cell therapy
Regulatory T cells (Treg cells) are a small subset of immune cells that are dedicated to
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …
Quantifiable predictive features define epitope-specific T cell receptor repertoires
T cells are defined by a heterodimeric surface receptor, the T cell receptor (TCR), that
mediates recognition of pathogen-associated epitopes through interactions with peptide and …
mediates recognition of pathogen-associated epitopes through interactions with peptide and …
Antigen-driven clonal selection shapes the persistence of HIV-1–infected CD4+ T cells in vivo
FR Simonetti, H Zhang, GP Soroosh… - The Journal of …, 2021 - Am Soc Clin Investig
Clonal expansion of infected CD4+ T cells is a major mechanism of HIV-1 persistence and a
barrier to achieving a cure. Potential causes are homeostatic proliferation, effects of HIV-1 …
barrier to achieving a cure. Potential causes are homeostatic proliferation, effects of HIV-1 …
Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer
S Stevanović, A Pasetto, SR Helman, JJ Gartner… - Science, 2017 - science.org
Immunotherapy has clinical activity in certain virally associated cancers. However, the tumor
antigens targeted in successful treatments remain poorly defined. We used a personalized …
antigens targeted in successful treatments remain poorly defined. We used a personalized …
Overview of methodologies for T-cell receptor repertoire analysis
Background The T-cell receptor (TCR), located on the surface of T cells, is responsible for
the recognition of the antigen-major histocompatibility complex, leading to the initiation of an …
the recognition of the antigen-major histocompatibility complex, leading to the initiation of an …
T cell fate and clonality inference from single-cell transcriptomes
We developed TraCeR, a computational method to reconstruct full-length, paired T cell
receptor (TCR) sequences from T lymphocyte single-cell RNA sequence data. TraCeR links …
receptor (TCR) sequences from T lymphocyte single-cell RNA sequence data. TraCeR links …
Prospects for gene-engineered T cell immunotherapy for solid cancers
CA Klebanoff, SA Rosenberg, NP Restifo - Nature medicine, 2016 - nature.com
Adoptive transfer of receptor-engineered T cells has produced impressive results in treating
patients with B cell leukemias and lymphomas. This success has captured public …
patients with B cell leukemias and lymphomas. This success has captured public …
Clinically resolved psoriatic lesions contain psoriasis-specific IL-17–producing αβ T cell clones
TR Matos, JT O'Malley, EL Lowry… - The Journal of …, 2017 - Am Soc Clin Investig
In psoriasis, an IL-17–mediated inflammatory skin disease, skin lesions resolve with therapy,
but often recur in the same locations when therapy is discontinued. We propose that residual …
but often recur in the same locations when therapy is discontinued. We propose that residual …
Understanding the drivers of MHC restriction of T cell receptors
T cell discrimination of self and non-self is predicated on αβ T cell receptor (TCR) co-
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …