Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a systemic infection

A Synowiec, A Szczepański… - Clinical microbiology …, 2021 - Am Soc Microbiol
To date, seven identified coronaviruses (CoVs) have been found to infect humans; of these,
three highly pathogenic variants have emerged in the 21st century. The newest member of …

Endothelium infection and dysregulation by SARS-CoV-2: evidence and caveats in COVID-19

I Bernard, D Limonta, LK Mahal, TC Hobman - Viruses, 2020 - mdpi.com
The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the acute
respiratory syndrome-coronavirus-2 (SARS-CoV-2) poses a persistent threat to global public …

Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice

AJ Pruijssers, AS George, A Schäfer, SR Leist… - Cell reports, 2020 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the novel viral disease COVID-19. With no approved therapies, this pandemic illustrates the …

[HTML][HTML] Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy

E Wyler, K Mösbauer, V Franke, A Diag, LT Gottula… - IScience, 2021 - cell.com
Detailed knowledge of the molecular biology of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection is crucial for understanding of viral replication, host …

No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor

J Shilts, TWM Crozier, EJD Greenwood, PJ Lehner… - Scientific reports, 2021 - nature.com
The spike protein of SARS-CoV-2 is known to enable viral invasion into human cells through
direct binding to host receptors including ACE2. An alternate entry receptor for the virus was …

Microstructure, pathophysiology, and potential therapeutics of COVID‐19: a comprehensive review

SP Singh, M Pritam, B Pandey… - Journal of medical …, 2021 - Wiley Online Library
There have been over seven million cases and almost 413 372 deaths globally due to the
novel coronavirus (2019‐nCoV) associated disease COVID‐19, as of 11 June 2020 …

Prioritization of anti‐SARS‐Cov‐2 drug repurposing opportunities based on plasma and target site concentrations derived from their established human …

U Arshad, H Pertinez, H Box, L Tatham… - Clinical …, 2020 - Wiley Online Library
There is a rapidly expanding literature on the in vitro antiviral activity of drugs that may be
repurposed for therapy or chemoprophylaxis against severe acute respiratory syndrome …

[HTML][HTML] Comprehensive analysis of drugs to treat SARS‑CoV‑2 infection: Mechanistic insights into current COVID‑19 therapies

GM Nitulescu, H Paunescu… - International …, 2020 - spandidos-publications.com
The major impact produced by the severe acute respiratory syndrome coronavirus 2 (SARS‑
CoV‑2) focused many researchers attention to find treatments that can suppress …

An enzymatic TMPRSS2 assay for assessment of clinical candidates and discovery of inhibitors as potential treatment of COVID-19

JH Shrimp, SC Kales, PE Sanderson… - ACS pharmacology & …, 2020 - ACS Publications
SARS-CoV-2 is the viral pathogen causing the COVID19 global pandemic. Consequently,
much research has gone into the development of preclinical assays for the discovery of new …

SARS-CoV-2 and SARS-CoV spike-mediated cell-cell fusion differ in their requirements for receptor expression and proteolytic activation

BF Hörnich, AK Großkopf, S Schlagowski… - Journal of …, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infects cells
through interaction of its spike protein (SARS2-S) with angiotensin-converting enzyme 2 …