The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME–Tox)
ATP binding cassette (ABC) drug transporters play an important role in cancer drug
resistance, protection against xenobiotics, and in general in the passage of drugs through …
resistance, protection against xenobiotics, and in general in the passage of drugs through …
Structure and function of the human breast cancer resistance protein (BCRP/ABCG2)
Z Ni, Z Bikadi, MF Rosenberg… - Current drug metabolism, 2010 - ingentaconnect.com
The human breast cancer resistance protein (BCRP/ABCG2) is the second member of the G
subfamily of the large ATPbinding cassette (ABC) transporter superfamily. BCRP was …
subfamily of the large ATPbinding cassette (ABC) transporter superfamily. BCRP was …
Multidrug efflux transporter ABCG2: expression and regulation
The adenosine triphosphate (ATP)-binding cassette efflux transporter G2 (ABCG2) was
originally discovered in a multidrug-resistant breast cancer cell line. Studies in the past have …
originally discovered in a multidrug-resistant breast cancer cell line. Studies in the past have …
[HTML][HTML] Diverse relations between ABC transporters and lipids: An overview
J Neumann, D Rose-Sperling, UA Hellmich - Biochimica et Biophysica Acta …, 2017 - Elsevier
It was first discovered in 1992 that P-glycoprotein (Pgp, ABCB1), an ATP binding cassette
(ABC) transporter, can transport phospholipids such as phosphatidylcholine,− ethanolamine …
(ABC) transporter, can transport phospholipids such as phosphatidylcholine,− ethanolamine …
[HTML][HTML] P-glycoproteins and other multidrug resistance transporters in the pharmacology of anthelmintics: prospects for reversing transport-dependent anthelmintic …
A Lespine, C Ménez, C Bourguinat… - International Journal for …, 2012 - Elsevier
Parasitic helminths cause significant disease in animals and humans. In the absence of
alternative treatments, anthelmintics remain the principal agents for their control. Resistance …
alternative treatments, anthelmintics remain the principal agents for their control. Resistance …
Role of ATP‐binding cassette transporters in brain lipid transport and neurological disease
WS Kim, CS Weickert, B Garner - Journal of neurochemistry, 2008 - Wiley Online Library
The brain is lipid‐rich compared to other organs and although previous studies have
highlighted the importance of ATP‐binding cassette (ABC) transporters in the regulation of …
highlighted the importance of ATP‐binding cassette (ABC) transporters in the regulation of …
The net electrostatic potential and hydration of ABCG2 affect substrate transport
T Gose, HM Aitken, Y Wang, J Lynch… - Nature …, 2023 - nature.com
ABCG2 is a medically important ATP-binding cassette transporter with crucial roles in the
absorption and distribution of chemically-diverse toxins and drugs, reducing the cellular …
absorption and distribution of chemically-diverse toxins and drugs, reducing the cellular …
Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2
ABCG2 is an ATP-binding cassette (ABC) transporter that extrudes a wide range of
xenobiotics and drugs from the cell and contributes to multidrug resistance in cancer cells …
xenobiotics and drugs from the cell and contributes to multidrug resistance in cancer cells …
[HTML][HTML] Membrane lipids and transporter function
B Stieger, J Steiger, KP Locher - … et Biophysica Acta (BBA)-Molecular Basis …, 2021 - Elsevier
Transport proteins are essential for cells in allowing the exchange of substances between
cells and their environment across the lipid bilayer forming a tight barrier. Membrane lipids …
cells and their environment across the lipid bilayer forming a tight barrier. Membrane lipids …