RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …

A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential,
are transcribed from the mammalian genome. They are emerging as important regulators in …

R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …

R-loops are three-stranded nucleic acid structures that are abundant and widespread across
the genome and that have important physiological roles in many nuclear processes. Their …

During transcription, the nascent RNA strand can base pair with its template DNA, displacing
the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are …

Hypoxia is a remarkable trait of the tumor microenvironment (TME). When facing selective
pressure, tumor cells show various adaptive characteristics, such as changes in the …

Alternative lengthening of telomeres (ALT), a telomerase-independent process maintaining
telomeres, is mediated by break-induced replication (BIR). RAD52 promotes ALT by …

A major shift in our understanding of genome regulation has emerged recently. It is now
apparent that the majority of cellular transcripts do not code for proteins, and many of them …

R-loops have both positive and negative impacts on chromosome functions. To identify toxic
R-loops in the human genome, here, we map RNA: DNA hybrids, replication stress markers …

PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is
triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was …