Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq
INTRODUCTION Tumor fitness, evolution, and resistance to therapy are governed by
selection of malignant cells with specific genotypes, by expression programs related to …
selection of malignant cells with specific genotypes, by expression programs related to …
The role of Rho GTPases in motility and invasion of glioblastoma cells
H Al-Koussa, OE Atat, L Jaafar… - Analytical Cellular …, 2020 - Wiley Online Library
Astrocytomas are primary malignant brain tumors that originate from astrocytes. Grade IV
astrocytoma or glioblastoma is a highly invasive tumor that occur within the brain …
astrocytoma or glioblastoma is a highly invasive tumor that occur within the brain …
[HTML][HTML] Mir-758-5p suppresses glioblastoma proliferation, migration and invasion by targeting ZBTB20
J Liu, J Jiang, X Hui, W Wang, D Fang… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: To determine the cellular functions and clinical significance of micro-758-
5p (miR-758-5p) in glioblastoma (GBM) by targeting zinc finger and BTB domain-containing …
5p (miR-758-5p) in glioblastoma (GBM) by targeting zinc finger and BTB domain-containing …
Molecular determinants of malignant brain cancers: from intracellular alterations to invasion mediated by extracellular vesicles
G Schiera, CM Di Liegro, I Di Liegro - International Journal of Molecular …, 2017 - mdpi.com
Malignant glioma cells invade the surrounding brain parenchyma, by migrating along the
blood vessels, thus promoting cancer growth. The biological bases of these activities are …
blood vessels, thus promoting cancer growth. The biological bases of these activities are …
Downregulation of the Rho GTPase pathway abrogates resistance to ionizing radiation in wild-type p53 glioblastoma by suppressing DNA repair mechanisms
YT Magalhaes, VK Boell, GD Cardella, FL Forti - Cell Death & Disease, 2023 - nature.com
Glioblastoma (GBM), the most common aggressive brain tumor, is characterized by rapid
cellular infiltration and is routinely treated with ionizing radiation (IR), but therapeutic …
cellular infiltration and is routinely treated with ionizing radiation (IR), but therapeutic …
[HTML][HTML] A novel tumor-suppressor, CDH18, inhibits glioma cell invasiveness via UQCRC2 and correlates with the prognosis of glioma patients
Background/Aims: CDH18 (cadherin 18) is specifically expressed in the central nervous
system and associated with various neuropsychiatric disorders. In this study, the role of …
system and associated with various neuropsychiatric disorders. In this study, the role of …
Multilayer omics reveals the molecular mechanism of early infection of Clonorchis sinensis juvenile
Y Wu, X Deng, Z Wu, D Liu, X Fu, L Tang, S He, J Lv… - Parasites & …, 2023 - Springer
Background Clonorchiasis remains a non-negligible global zoonosis, causing serious
socioeconomic burdens in endemic areas. Clonorchis sinensis infection typically elicits …
socioeconomic burdens in endemic areas. Clonorchis sinensis infection typically elicits …
Upfront boost Gamma Knife “leading-edge” radiosurgery to FLAIR MRI–defined tumor migration pathways in 174 patients with glioblastoma multiforme: a 15-year …
CM Duma, BS Kim, PV Chen, ME Plunkett… - Journal of …, 2016 - thejns.org
OBJECTIVE Glioblastoma multiforme (GBM) is composed of cells that migrate through the
brain along predictable white matter pathways. Targeting white matter pathways adjacent to …
brain along predictable white matter pathways. Targeting white matter pathways adjacent to …
A CRISPR Activation screen identifies an atypical rho GTPase that enhances Zika viral entry
AP Luu, Z Yao, S Ramachandran, SA Azzopardi… - Viruses, 2021 - mdpi.com
Zika virus (ZIKV) is a re-emerging flavivirus that has caused large-scale epidemics. Infection
during pregnancy can lead to neurologic developmental abnormalities in children. There is …
during pregnancy can lead to neurologic developmental abnormalities in children. There is …
[HTML][HTML] The epigenetic factor KDM2B regulates cell adhesion, small rho GTPases, actin cytoskeleton and migration in prostate cancer cells
N Zacharopoulou, A Tsapara, G Kallergi… - … et Biophysica Acta (BBA …, 2018 - Elsevier
The histone demethylase KDM2B is an epigenetic factor with oncogenic properties that is
regulated by the basic fibroblasts growth factor (FGF-2). It has recently been shown that …
regulated by the basic fibroblasts growth factor (FGF-2). It has recently been shown that …