Environmental influences on the pace of brain development
Childhood socio-economic status (SES), a measure of the availability of material and social
resources, is one of the strongest predictors of lifelong well-being. Here we review evidence …
resources, is one of the strongest predictors of lifelong well-being. Here we review evidence …
Animal models of major depression: drawbacks and challenges
Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …
Early life adversity shapes neural circuit function during sensitive postnatal developmental periods
Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological
mechanisms by which ELA increases the risk for future psychopathology are still poorly …
mechanisms by which ELA increases the risk for future psychopathology are still poorly …
Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses
Several mental illnesses, characterized by aberrant stress reactivity, often arise after early-
life adversity (ELA). However, it is unclear how ELA affects stress-related brain circuit …
life adversity (ELA). However, it is unclear how ELA affects stress-related brain circuit …
Early life adversity shapes social subordination and cell type–specific transcriptomic patterning in the ventral hippocampus
Adverse events in early life can modulate the response to additional stressors later in life
and increase the risk of developing psychiatric disorders. The underlying molecular …
and increase the risk of developing psychiatric disorders. The underlying molecular …
The cortisol switch between vulnerability and resilience
ER de Kloet, M Joëls - Molecular Psychiatry, 2024 - nature.com
In concert with neuropeptides and transmitters, the end products of the hypothalamus-
pituitary-adrenal (HPA) axis, the glucocorticoid hormones cortisol and corticosterone …
pituitary-adrenal (HPA) axis, the glucocorticoid hormones cortisol and corticosterone …
Early life stress leads to sex differences in development of depressive-like outcomes in a mouse model
HL Goodwill, G Manzano-Nieves, M Gallo… - …, 2019 - nature.com
Childhood trauma and neglect influence emotional development and increase the risk for
and severity of mental illness. Women have a heightened susceptibility to the effects of early …
and severity of mental illness. Women have a heightened susceptibility to the effects of early …
Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice
Disrupted operations of the reward circuit underlie major emotional disorders, including
depression, which commonly arise following early life stress/adversity (ELA). However, how …
depression, which commonly arise following early life stress/adversity (ELA). However, how …
Neurodevelopmental optimization after early-life adversity: cross-species studies to elucidate sensitive periods and brain mechanisms to inform early intervention
Human brain development is influenced by early-life experiences, particularly during
sensitive periods, with impact on cognitive and emotional outcomes. Understanding how the …
sensitive periods, with impact on cognitive and emotional outcomes. Understanding how the …
Early-life adversity and neurological disease: age-old questions and novel answers
Neurological illnesses, including cognitive impairment, memory decline and dementia, affect
over 50 million people worldwide, imposing a substantial burden on individuals and society …
over 50 million people worldwide, imposing a substantial burden on individuals and society …