Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies
NN Keum, E Giovannucci - Nature reviews Gastroenterology & …, 2019 - nature.com
Globally, colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the
second leading cause of cancer death. Arising through three major pathways, including …
second leading cause of cancer death. Arising through three major pathways, including …
Epidemiology and mechanisms of the increasing incidence of colon and rectal cancers in young adults
EM Stoffel, CC Murphy - Gastroenterology, 2020 - Elsevier
In contrast to the decreasing incidence of colorectal cancer (CRC) in older populations, the
incidence has nearly doubled in younger adults since the early 1990s. Approximately 1 in …
incidence has nearly doubled in younger adults since the early 1990s. Approximately 1 in …
[HTML][HTML] Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions
Genetic variation can predispose to disease both through (i) monogenic risk variants that
disrupt a physiologic pathway with large effect on disease and (ii) polygenic risk that …
disrupt a physiologic pathway with large effect on disease and (ii) polygenic risk that …
[HTML][HTML] Development of a clinical polygenic risk score assay and reporting workflow
Implementation of polygenic risk scores (PRS) may improve disease prevention and
management but poses several challenges: the construction of clinically valid assays …
management but poses several challenges: the construction of clinically valid assays …
Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche
M Roulis, A Kaklamanos, M Schernthanner, P Bielecki… - Nature, 2020 - nature.com
The initiation of an intestinal tumour is a probabilistic process that depends on the
competition between mutant and normal epithelial stem cells in crypts. Intestinal stem cells …
competition between mutant and normal epithelial stem cells in crypts. Intestinal stem cells …
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries
Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-
wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of …
wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of …
[PDF][PDF] Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis
Little is known about how interactions of diet, intestinal stem cells (ISCs), and immune cells
affect early-stage intestinal tumorigenesis. We show that a high-fat diet (HFD) reduces the …
affect early-stage intestinal tumorigenesis. We show that a high-fat diet (HFD) reduces the …
[PDF][PDF] Genome-wide modeling of polygenic risk score in colorectal cancer risk
M Thomas, LC Sakoda, M Hoffmeister… - The American journal of …, 2020 - cell.com
Accurate colorectal cancer (CRC) risk prediction models are critical for identifying
individuals at low and high risk of developing CRC, as they can then be offered targeted …
individuals at low and high risk of developing CRC, as they can then be offered targeted …
Genome-wide polygenic score to predict chronic kidney disease across ancestries
Chronic kidney disease (CKD) is a common complex condition associated with high
morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; …
morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; …
[HTML][HTML] Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis
Physical activity has been associated with lower risks of breast and colorectal cancer in
epidemiological studies; however, it is unknown if these associations are causal or …
epidemiological studies; however, it is unknown if these associations are causal or …