MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by
degrading or repressing the translation of their target messenger RNAs. As miRNAs are …

A common lament is that long-term kidney transplant outcomes remain the same despite
improvements in early graft survival. To be fair, progress has been made—in both our …

Background: Antibody-mediated rejection (AMR) contributes to heart allograft loss. However,
an important knowledge gap remains in terms of the pathophysiology of AMR and how …

Aim Rejection is one of the major causes of late cardiac allograft failure and at present can
only be diagnosed by invasive endomyocardial biopsies. We sought to determine whether …

Since aberrant miRNA expression has been implicated in numerous brain diseases, we
studied miRNA expression and miRNA regulation of important signaling pathways during …

The immunological role of exosomes in allograft rejection remains unknown. We sought to
determine whether exosomes are induced during lung allograft rejection and to define the …

MicroRNAs are epigenetic regulators of gene expression at the posttranscriptional level.
They are involved in intercellular communication and crosstalk between different organs. As …

A growing number of patients with end-stage lung disease have benefited from lung
transplantation (LT). Improvements in organ procurement, surgical techniques and intensive …

Although current regimens of immunosuppressive drugs are effective in renal transplant
recipients, long-term renal allograft outcomes remain suboptimal. For many years, the …

Ever since the discovery of the major histocompatibility complex, scientific and clinical
understanding in the field of transplantation has been advanced through genetic and …