Bone remodeling and the role of TRAF3 in osteoclastic bone resorption

BF Boyce, J Li, L Xing, Z Yao - Frontiers in immunology, 2018 - frontiersin.org
Skeletal health is maintained by bone remodeling, a process in which microscopic sites of
effete or damaged bone are degraded on bone surfaces by osteoclasts and subsequently …

[HTML][HTML] Novel insights into the coupling of osteoclasts and resorption to bone formation

MM Durdan, RD Azaria, MM Weivoda - Seminars in cell & developmental …, 2022 - Elsevier
Bone remodeling consists of resorption by osteoclasts (OCs) and formation by osteoblasts
(OBs). Precise coordination of these activities is required for the resorbed bone to be …

Repurposing chloroquine against multiple diseases with special attention to SARS-CoV-2 and associated toxicity

S Kamat, M Kumari - Frontiers in Pharmacology, 2021 - frontiersin.org
Chloroquine and its derivatives have been used since ages to treat malaria and have also
been approved by the FDA to treat autoimmune diseases. The drug employs pH-dependent …

Osteoporosis in rheumatic diseases: anti-rheumatic drugs and the skeleton

AM Dubrovsky, MJ Lim, NE Lane - Calcified tissue international, 2018 - Springer
Osteoporosis in rheumatic diseases is a very well-known complication. Systemic
inflammation results in both generalized and localized bone loss and erosions. Recently …

Bisphosphonates for delivering drugs to bone

S Sun, J Tao, PP Sedghizadeh… - British journal of …, 2021 - Wiley Online Library
Advances in the design of potential bone‐selective drugs for the treatment of various bone‐
related diseases are creating exciting new directions for multiple unmet medical needs. For …

Spirulina protein concentrate hydrogel reinforced by hydroxyapatite nanoparticles and hydroxychloroquin: A novel platform for bone regeneration

M Azimi, J Varshosaz, M Mirian - Materials Today Communications, 2024 - Elsevier
Among the fabrication methods, hydrogels have received significant attention due to their
excellent ability to mimic the extracellular matrix structure. Spirulina is a type of unicellular …

Associations between osteoporosis and drug exposure: a post-marketing study of the World Health Organization pharmacovigilance database (VigiBase®)

B Batteux, Y Bennis, S Bodeau, K Masmoudi… - Bone, 2021 - Elsevier
Background Bone remodeling is a complex process, and many conditions (including drug
exposure) lead to osteoporosis. Here, we sought to detect new disproportionality signals for …

The effect of anti-rheumatic drugs on the skeleton

B Hauser, H Raterman, SH Ralston… - Calcified Tissue …, 2022 - Springer
The therapeutic armamentarium for rheumatoid arthritis has increased substantially over the
last 20 years. Historically antirheumatic treatment was started late in the disease course and …

Challenges and opportunities for osteoporosis care during the COVID-19 pandemic

SJ Cromer, EW Yu - The Journal of Clinical Endocrinology & …, 2021 - academic.oup.com
Purpose The coronavirus disease 2019 (COVID-19) has both directly and indirectly affected
osteoporosis diagnosis and treatment throughout the world. Methods This mini-review …

Icariin prevents diabetes-induced bone loss in rats by reducing blood glucose and suppressing bone turnover

S Qi, J He, H Zheng, C Chen, S Lan - Molecules, 2019 - mdpi.com
Diabetic Osteoporosis (DOP) is a common metabolic bone disease, characterized by
decreased bone mineral density (BMD) and destruction of bone microstructure. It has been …