Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

The discovery of clustered regularly interspaced short palindromic repeats (CRISPR)
genome editing technology opened the door to provide a versatile approach for treating …

Cellular reprogramming can manipulate the identity of cells to generate the desired cell
types,–. The use of cell intrinsic components, including oocyte cytoplasm and transcription …

In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …

Epigenomic profiling has enabled large-scale identification of regulatory elements, yet we
still lack a systematic mapping from any sequence or variant to regulatory activities. We …

Epithelial-to-mesenchymal transition (EMT) and its reversed process, mesenchymal-to-
epithelial transition (MET), are fundamental processes in embryonic development and tissue …

INTRODUCTION Cancer is one of the leading causes of death worldwide. Although the 2%
of the human genome that encodes proteins has been extensively studied, much remains to …

Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …

Methods for quantifying gene expression and chromatin accessibility in single cells are well
established, but single-cell analysis of chromatin regions with specific histone modifications …