Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Wnt signaling plays an important role in development and disease. In this review we focus
on the role of the canonical Wnt signaling pathway in somatic stem cell biology and its …

Chronic cardiac stress induces pathologic hypertrophy and fibrosis of the myocardium. The
microRNA-29 (miR-29) family has been found to prevent excess collagen expression in …

Estrogens are known to regulate the proliferation of breast cancer cells and to alter their
cytoarchitectural and phenotypic properties, but the gene networks and pathways by which …

Myeloid‐derived suppressor cells (MDSCs) play a pivotal role in mediating the formation of
an immunosuppressive environment and assisting tumors in evading the host immune …

The mechanisms by which transcription factor haploinsufficiency alters the epigenetic and
transcriptional landscape in human cells to cause disease are unknown. Here, we utilized …

Due to narrow therapeutic window of cancer therapeutic agents and the development of
resistance against these agents, there is a need to discover novel agents to treat breast …

The p38 proteins are an evolutionally conserved family of mitogen-activated protein kinases
(MAPK). Recent studies have led to progress in our understanding the roles of p38 MAPK in …

Since the relationship between TCF7L2 (also known as TCF-4) polymorphisms and type 2
diabetes mellitus was identified in 2006, extensive genome-wide association examinations …

Wnt proteins are a large family of secreted glycoproteins. Wnt proteins bind to the Frizzled
receptors and LRP5/6 co-receptors, and through stabilizing the critical mediator β-catenin …