Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and
proliferation. As such, most human cancers differ from normal counterpart tissues by a …

MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

FOXO3a is a member of the FOXO subfamily of forkhead transcription factors that mediate a
variety of cellular processes including apoptosis, proliferation, cell cycle progression, DNA …

The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …

FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor
that is widely spatiotemporally expressed during the cell cycle. It is closely involved with the …

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

Endothelial cells (ECs) are plastic cells that can switch between growth states with different
bioenergetic and biosynthetic requirements. Although quiescent in most healthy tissues …

Forkhead box O (FOXO) transcription factors are involved in the regulation of the cell cycle,
apoptosis and metabolism. In model organisms, FOXO activity also affects stem cell …

Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for
fine-tuning the spatial and temporal expression of a broad range of genes both during …

Background: The gene FOXO3, encoding the transcription factor forkhead box O-3 (FoxO3),
is one of only two for which genetic polymorphisms have exhibited consistent associations …