Implications and mechanism of action of gabapentin in neuropathic pain

A Kukkar, A Bali, N Singh, AS Jaggi - Archives of pharmacal research, 2013 - Springer
Gabapentin is an anti-epileptic agent but now it is also recommended as first line agent in
neuropathic pain, particularly in diabetic neuropathy and post herpetic neuralgia. α2δ-1, an …

Pregabalin in neuropathic pain: evidences and possible mechanisms

V Verma, N Singh, A Singh Jaggi - Current neuropharmacology, 2014 - ingentaconnect.com
Pregabalin is an antagonist of voltage gated Ca2+ channels and specifically binds to alpha-
2-delta subunit to produce antiepileptic and analgesic actions. It successfully alleviates the …

Cardiovascular risk of gabapentin and pregabalin in patients with diabetic neuropathy

Y Pan, PB Davis, DC Kaebler, RP Blankfield… - Cardiovascular …, 2022 - Springer
Background Gabapentin and pregabalin are commonly prescribed medications to treat pain
in patients with diabetic neuropathy. Gabapentin and pregabalin can cause fluid retention …

Profiles of pregabalin and gabapentin abuse by postmortem toxicology

M Häkkinen, E Vuori, E Kalso, M Gergov… - Forensic science …, 2014 - Elsevier
Pregabalin (PRG) and gabapentin (GBP) are used in the treatment of neuropathic pain and
epilepsy, and PRG also in generalized anxiety disorder. There is increasing evidence that …

Pregabalin for the treatment of generalized anxiety disorder: an update

DS Baldwin, K Ajel, VG Masdrakis… - … disease and treatment, 2013 - Taylor & Francis
A previous review summarized what was then known about the potential role of pregabalin
in the treatment of patients with generalized anxiety disorder (GAD): this review provides an …

Choice of antiepileptic drugs for the elderly: possible drug interactions and adverse effects

SM Jankovic, M Dostic - Expert opinion on drug metabolism & …, 2012 - Taylor & Francis
Introduction: Antiepileptic drugs are prescribed to patients of all ages and are commonly
prescribed to patients over the age of 65. When prescribing these drugs to patients of this …

Neuropathic pain, depression, and cardiovascular disease: a national multicenter study

JJ Cragg, VK Noonan, L Noreau, JF Borisoff… - …, 2015 - karger.com
Background: Individuals with spinal cord injury (SCI) have a more than twofold increased
risk of heart disease and stroke compared with able-bodied individuals. The increased risk …

Clinical utility, safety, and efficacy of pregabalin in the treatment of fibromyalgia

S Bhusal, S Diomampo, MN Magrey - Drug, Healthcare and Patient …, 2016 - Taylor & Francis
Fibromyalgia is a chronic debilitating medical syndrome with limited therapeutic options.
Pregabalin, an anticonvulsant and α-2-Δ subunit receptor ligand, is one of the anchor drugs …

Assessment of pregabalin-induced cardiotoxicity in rats: mechanistic role of angiotensin 1–7

ZM Awwad, SO El-Ganainy, AI ElMallah… - Cardiovascular …, 2020 - Springer
Pregabalin (PRG) possesses great therapeutic benefits in the treatment of epilepsy,
neuropathic pain, and fibromyalgia. However, clinical data have reported incidence or …

[HTML][HTML] Convulsive syncope induced by ventricular arrhythmia masquerading as epileptic seizures: case report and literature review

J Sabu, K Regeti, M Mallappallil, J Kassotis… - Journal of clinical …, 2016 - ncbi.nlm.nih.gov
It is important but difficult to distinguish convulsive syncope from epileptic seizure in many
patients. We report a case of a man who presented to emergency department after several …