There has been an explosion in our knowledge of the pathways and mechanisms by which
the immune system can influence the brain and behavior. In the context of inflammation, pro …

Much attention has been paid to the potential role of the immune system in the
pathophysiology of major depression in humans. While activation of innate immune …

Chromatin remodeling such as changes in histone acetylation has been suggested to play
an important role in the pathophysiology and treatment of mood disorders. In the present …

Depression is one of the most frequently diagnosed condition in psychiatry. Despite the
availability of many preparations, over 30% of treated patients do not achieve remission …

There is an abundance of evidence suggesting the involvement of altered levels of
expression of neurotrophic factors in the pathophysiology of neuropsychiatric disorders …

Alterations in brain plasticity are increasingly thought to play important roles in major
depressive disorder (MDD) and suicide. To gain a better understanding of the gross …

Sirtuins are a family of NAD+-dependent enzymes that regulate cellular functions through
deacetylation of various proteins. Although recent reports have suggested an important role …

Social stress is a risk factor for psychiatric disorders, however only a subset of the population
is susceptible while others remain resilient. Inflammation has been linked to the …

Historically the monoaminergic neurotransmitter system, in particular the serotonergic
system, was seen as being responsible for the pathophysiology of major depressive …

Depression is currently one of the most common psychiatric disorders and the number of
patients receiving antidepressant treatment is increasing every year. Therefore, it is …