The Warburg effect modulates DHODH role in ferroptosis: a review
A Amos, A Amos, L Wu, H Xia - Cell Communication and Signaling, 2023 - Springer
Ferroptosis is an iron-dependent regulated cell death that suppresses tumor growth. It is
activated by extensive peroxidation of membrane phospholipids caused by oxidative stress …
activated by extensive peroxidation of membrane phospholipids caused by oxidative stress …
[HTML][HTML] Nucleotide metabolism in the regulation of tumor microenvironment and immune cell function
HB Madsen, MJW Peeters, P thor Straten… - Current opinion in …, 2023 - Elsevier
Highlights•Nucleotide metabolism.•Tumor microenvironment.•Immune cells.•Cancer
therapy.•Immunotherapy.Nucleotide metabolism plays a crucial role in the regulation of the …
therapy.•Immunotherapy.Nucleotide metabolism plays a crucial role in the regulation of the …
OXPHOS inhibitors, metabolism and targeted therapies in cancer
O Cadassou, LP Jordheim - Biochemical Pharmacology, 2023 - Elsevier
More and more studies highlight the complex metabolic characteristics and plasticity of
cancer cells. To address these specificities and explore the associated vulnerabilities, new …
cancer cells. To address these specificities and explore the associated vulnerabilities, new …
[HTML][HTML] Human fibroblasts from sporadic Alzheimer's disease (AD) patients show mitochondrial alterations and lysosome dysfunction
Mitophagy is a mechanism that maintains mitochondrial integrity and homeostasis and is
thought to promote longevity and reduce the risk of age-related neurodegenerative …
thought to promote longevity and reduce the risk of age-related neurodegenerative …
DHODH: a promising target in the treatment of T-cell acute lymphoblastic leukemia
AN Sexauer, G Alexe, K Gustafsson… - Blood …, 2023 - ashpublications.org
Patients with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) have a poor
prognosis with few therapeutic options. With the goal of identifying novel therapeutic targets …
prognosis with few therapeutic options. With the goal of identifying novel therapeutic targets …
[HTML][HTML] Inhibition of FSP1: A new strategy for the treatment of tumors
Q Dai, X Wei, J Zhao, D Zhang, Y Luo… - Oncology …, 2024 - spandidos-publications.com
Ferroptosis, a regulated form of cell death, is intricately linked to iron‑dependent lipid
peroxidation. Recent evidence strongly supports the induction of ferroptosis as a promising …
peroxidation. Recent evidence strongly supports the induction of ferroptosis as a promising …