Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …

H2A. Z is a histone variant that provides specific structural and docking-side properties to the
nucleosome, resulting in diverse and specialised molecular and cellular functions. In this …

In the past few decades, the field of neuroepigenetics has investigated how the brain
encodes information to form long-lasting memories that lead to stable changes in behaviour …

The basic unit of chromatin, the nucleosome, is an octamer of four core histone proteins
(H2A, H2B, H3, and H4) and serves as a fundamental regulatory unit in all DNA-templated …

Cancer is a complex disease characterized by loss of cellular homeostasis through genetic
and epigenetic alterations. Emerging evidence highlights a role for histone variants and their …

Schizophrenia (SZ) is a psychiatric disorder with complex genetic risk dictated by
interactions between hundreds of risk variants. Epigenetic factors, such as histone …

Summary The developmental disorder Floating-Harbor syndrome (FHS) is caused by
heterozygous truncating mutations in SRCAP, a gene encoding a chromatin remodeler …

Neurons are dynamic cells that respond and adapt to stimuli throughout their long
postmitotic lives. The structural and functional plasticity of neurons requires the regulated …

Histone variants were recently discovered to regulate neural plasticity, with H2A. Z emerging
as a memory suppressor. Using whole-genome sequencing of the mouse hippocampus, we …