Gastric cancer is among the most common malignancies worldwide, characterized by
geographical, epidemiological and histological heterogeneity. Here, we report an extensive …

Tumour risk syndromes (TRS) are characterized by an increased risk of early-onset cancers
in a familial context. High cancer risk is mostly driven by loss-of-function variants in a single …

Simple Summary During embryonic development, cells proliferate and move to form
structures essential to each organ. As these dynamic processes occur cells must form …

Abstract Purpose Orofacial clefts (OFCs) are common birth defects including cleft lip, cleft lip
and palate, and cleft palate. OFCs have heterogeneous etiologies, complicating clinical …

Background Germline mutations of E-cadherin contribute to hereditary diffuse gastric cancer
(HDGC) and congenital malformations, such as oral facial clefts (OFC). However, the …

Cleft lip and cleft palate are common birth defects resulting from genetic and/or
environmental perturbations of facial development in utero. Facial morphogenesis …

Featured Application The antiproliferative effects of Azima tetracantha support its traditional
uses; additionally, it may emerge as a possible source of promising anticancer biomolecules …

Objective: Congenital, non-syndromic orofacial clefts (CL/P) are infrequently monogenic in
etiology. However, heterozygous pathogenic CDH1 germline variants were reported in a few …

Simple Summary Congenital abnormalities in animals are a major concern for breeders due
to the increased economic loss they entail. The aim of this article was to describe a …

Malformative syndromes due to CDH1 pathogenic variants (PV) include non-syndromic cleft
lip or palate (CLP) and the blepharocheilodontic syndrome (BCDS). CDH1 was initially …