Thiazole ring—A biologically active scaffold

A Petrou, M Fesatidou, A Geronikaki - Molecules, 2021 - mdpi.com
Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …

Thiazole in the targeted anticancer drug discovery

A Ayati, S Emami, S Moghimi… - Future medicinal …, 2019 - Taylor & Francis
Cancer is known as one of the main causes of death in the world; and many compounds
have been synthesized to date with potential use in cancer therapy. Thiazole is a versatile …

The bioactivity of thiazolidin-4-ones: A short review of the most recent studies

D Mech, A Kurowska, N Trotsko - International Journal of Molecular …, 2021 - mdpi.com
Thiazolidin-4-ones is an important heterocyclic ring system of a pharmacophore and a
privileged scaffold in medicinal chemistry. This review is focused on the latest scientific …

An electrochemical-enabled cascaded cyclization of enaminones with potassium thiocyanate and alcohols to access 2-alkoxythiazoles

D Li, L Chen, Y Jin, X Wang, L Liu, Y Li, G Chen… - Green …, 2023 - pubs.rsc.org
An electrochemical-enabled three-component cascaded cyclization of enaminones with
potassium thiocyanate and alcohols to access 2-alkoxythiazoles has been developed under …

One-pot strategy for thiazole tethered 7-ethoxy quinoline hybrids: Synthesis and potential antimicrobial agents as dihydrofolate reductase (DHFR) inhibitors with …

YA Ammar, SMA Abd El-Hafez, SA Hessein… - Journal of Molecular …, 2021 - Elsevier
Over the world and especially the developing countries, one of the major threats to human
health is antibiotic resistance due to antibiotics abuse. This challenge can be solved by …

Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors

AM Srour, NS Ahmed, SS Abd El-Karim… - Bioorganic & Medicinal …, 2020 - Elsevier
Heterocyclic rings such as thiazole and benzimidazole are considered as privileged
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …

Potential Fluorinated Anti‐MRSA Thiazolidinone Derivatives with Antibacterial, Antitubercular Activity and Molecular Docking Studies

V Kumar, P Shetty, A HS, S Chandra K… - Chemistry & …, 2022 - Wiley Online Library
MRSA infection is one of the alarming diseases in the current scenario. Identifying newer
molecules to treat MRSA infection is of urgent need. In the present study, we have designed …

Thiazole–chalcone hybrids as prospective antitubercular and antiproliferative agents: Design, synthesis, biological, molecular docking studies and in silico ADME …

AB Kasetti, I Singhvi, R Nagasuri, RR Bhandare… - Molecules, 2021 - mdpi.com
Compounds bearing thiazole and chalcone pharmacophores have been reported to
possess excellent antitubercular and anticancer activities. In view of this, we designed …

A comprehensive review on thiazole based conjugates as anti-cancer agents

R Rana, N Kumar, HK Gulati, A Sharma… - Journal of Molecular …, 2023 - Elsevier
Over the past few decades, a significant number of anticancer drugs have been developed,
both natural and synthetic. Thiazole, a 5-membered distinctive heterocyclic motif with …

5-Adamantan thiadiazole-based thiazolidinones as antimicrobial agents. Design, synthesis, molecular docking and evaluation

M Fesatidou, P Zagaliotis, C Camoutsis… - Bioorganic & Medicinal …, 2018 - Elsevier
In continuation of our efforts to develop new compounds with antimicrobial properties we
describe design, synthesis, molecular docking study and evaluation of antimicrobial activity …