Progresses over the past years have extensively improved our capacity to use genome-
scale analyses—including high-density genotyping and exome and genome sequencing …

Introduction Neuroblastoma (NB) is the prime cancer of infancy, and accounts for 9% of
pediatric cancer deaths. While children diagnosed with clinically stable NB experience a …

Background High-risk neuroblastoma is a complex genetic disease that is lethal in more
than 50% of patients despite intense multimodal therapy. Through genome-wide association …

Our previous studies demonstrated that MEG3 was significantly downregulated in
neuroblastoma (NB) and its expression was negatively associated with the INSS stage …

Background FGFR1 regulates cell–cell adhesion and extracellular matrix architecture and
acts as oncogene in several cancers. Potential cancer driver mutations of FGFR1 occur in …

Br east Ca ncer 1 (BRCA1) gene is a well-characterized tumor suppressor gene, mutations
of which are primarily found in women with breast and ovarian cancers. B RCA1-a ssociated …

High-Risk neuroblastoma (NB) survival rate is still< 50%, despite treatments being more and
more aggressive. The biggest hurdle liable to cancer therapy failure is the drug resistance …

Breast cancer gene 1 (BRCA1)-associated RING domain protein 1 (BARD1) forms a
heterodimer with BRCA1, a tumor suppressor associated with hereditary breast and ovarian …

Abstract Genome-Wide Association Studies (GWAS) have been decisive in elucidating the
genetic predisposition of neuroblastoma (NB). The majority of genetic variants identified in …

Simple Summary RNA binding proteins (RBPs) post-transcriptionally regulate and stabilize
a variety of target mRNA transcripts. Human Antigen R (HuR) binds to several pro-survival …