Nucleosome positioning and gene regulation: advances through genomics

C Jiang, BF Pugh - Nature Reviews Genetics, 2009 - nature.com
Knowing the precise locations of nucleosomes in a genome is key to understanding how
genes are regulated. Recent'next generation'ChIP–chip and ChIP–Seq technologies have …

From DNA sequence to transcriptional behaviour: a quantitative approach

E Segal, J Widom - Nature Reviews Genetics, 2009 - nature.com
Complex transcriptional behaviours are encoded in the DNA sequences of gene regulatory
regions. Advances in our understanding of these behaviours have been recently gained …

BioSeq-BLM: a platform for analyzing DNA, RNA and protein sequences based on biological language models

HL Li, YH Pang, B Liu - Nucleic acids research, 2021 - academic.oup.com
In order to uncover the meanings of 'book of life', 155 different biological language models
(BLMs) for DNA, RNA and protein sequence analysis are discussed in this study, which are …

iLearnPlus: a comprehensive and automated machine-learning platform for nucleic acid and protein sequence analysis, prediction and visualization

Z Chen, P Zhao, C Li, F Li, D Xiang… - Nucleic acids …, 2021 - academic.oup.com
Sequence-based analysis and prediction are fundamental bioinformatic tasks that facilitate
understanding of the sequence (-structure)-function paradigm for DNAs, RNAs and proteins …

The Sorghum bicolor reference genome: improved assembly, gene annotations, a transcriptome atlas, and signatures of genome organization

RF McCormick, SK Truong, A Sreedasyam… - The Plant …, 2018 - Wiley Online Library
Sorghum bicolor is a drought tolerant C4 grass used for the production of grain, forage,
sugar, and lignocellulosic biomass and a genetic model for C4 grasses due to its relatively …

iLearn: an integrated platform and meta-learner for feature engineering, machine-learning analysis and modeling of DNA, RNA and protein sequence data

Z Chen, P Zhao, F Li, TT Marquez-Lago… - Briefings in …, 2020 - academic.oup.com
With the explosive growth of biological sequences generated in the post-genomic era, one
of the most challenging problems in bioinformatics and computational biology is to …

Pse-in-One: a web server for generating various modes of pseudo components of DNA, RNA, and protein sequences

B Liu, F Liu, X Wang, J Chen, L Fang… - Nucleic acids …, 2015 - academic.oup.com
With the avalanche of biological sequences generated in the post-genomic age, one of the
most challenging problems in computational biology is how to effectively formulate the …

A survey on ensemble learning under the era of deep learning

Y Yang, H Lv, N Chen - Artificial Intelligence Review, 2023 - Springer
Due to the dominant position of deep learning (mostly deep neural networks) in various
artificial intelligence applications, recently, ensemble learning based on deep neural …

BioSeq-Analysis: a platform for DNA, RNA and protein sequence analysis based on machine learning approaches

B Liu - Briefings in bioinformatics, 2019 - academic.oup.com
With the avalanche of biological sequences generated in the post-genomic age, one of the
most challenging problems is how to computationally analyze their structures and functions …

[HTML][HTML] Whole-genome sequencing in autism identifies hot spots for de novo germline mutation

JJ Michaelson, Y Shi, M Gujral, H Zheng, D Malhotra… - Cell, 2012 - cell.com
De novo mutation plays an important role in autism spectrum disorders (ASDs). Notably,
pathogenic copy number variants (CNVs) are characterized by high mutation rates. We …