Malate dehydrogenase as a multi-purpose target for drug discovery
CS Fermaintt, SA Wacker - Essays in Biochemistry, 2024 - portlandpress.com
Malate dehydrogenase (MDH) enzymes play critical roles in cellular metabolism, facilitating
the reversible conversion of malate to oxaloacetate using NAD+/NADH as a cofactor. The …
the reversible conversion of malate to oxaloacetate using NAD+/NADH as a cofactor. The …
Physiology of malate dehydrogenase and how dysregulation leads to disease
AD Parente, DE Bolland, KL Huisinga… - Essays in …, 2024 - portlandpress.com
Malate dehydrogenase (MDH) is pivotal in mammalian tissue metabolism, participating in
various pathways beyond its classical roles and highlighting its adaptability to cellular …
various pathways beyond its classical roles and highlighting its adaptability to cellular …
[HTML][HTML] FoxO3a Drives the Metabolic Reprogramming in Tamoxifen-Resistant Breast Cancer Cells Restoring Tamoxifen Sensitivity
Tamoxifen-resistant breast cancer cells (TamR-BCCs) are characterized by an enhanced
metabolic phenotype compared to tamoxifen-sensitive cells. FoxO3a is an important …
metabolic phenotype compared to tamoxifen-sensitive cells. FoxO3a is an important …
Malate dehydrogenase (MDH) in cancer: a promiscuous enzyme, a redox regulator, and a metabolic co-conspirator
B Leverett, S Austin, J Tan-Arroyo - Essays in Biochemistry, 2024 - portlandpress.com
Malate dehydrogenase (MDH) is an essential enzyme in the tricarboxylic acid cycle that
functions in cellular respiration and redox homeostasis. Recent studies indicate that MDH …
functions in cellular respiration and redox homeostasis. Recent studies indicate that MDH …
Insights into the regulation of malate dehydrogenase: inhibitors, activators, and allosteric modulation by small molecules
BM Martinez-Vaz, AL Howard… - Essays in …, 2024 - portlandpress.com
Cellular metabolism comprises a complex network of biochemical anabolic and catabolic
processes that fuel the growth and survival of living organisms. The enzyme malate …
processes that fuel the growth and survival of living organisms. The enzyme malate …
Discovery of novel chrysin derivatives as potential Anti-Psoriasis agents
X Zhao, C Du, Y Zeng, Y Chen, J Xu, X Yin, C Hu… - Bioorganic …, 2024 - Elsevier
Psoriasis is a chronic inflammatory disease and is difficult to cure. In this work, a series of
novel chrysin derivatives have been designed and prepared while evaluating anti …
novel chrysin derivatives have been designed and prepared while evaluating anti …