p73 and p63 are two homologs of the tumor suppressive transcription factor p53. Given the
high degree of structural similarity shared by the p53 family members, p73 and p63 can bind …

The transcription factor p63 is essential for the formation of the epidermis and other
stratifying epithelia. This is clearly demonstrated by the severe abnormality of p63-deficient …

During development, multipotent progenitor cells establish tissue-specific programs of gene
expression. In this paper, we show that p63 transcription factor, a master regulator of …

The skin is the largest organ in the body and plays multiple essential roles ranging from
regulating temperature, preventing infection and ultimately defining who we are physically. It …

Head and neck squamous cell carcinoma (HNSCC) and many other epithelial malignancies
exhibit increased proliferation, invasion, and inflammation, concomitant with aberrant …

Simple Summary In normal cells, p53 is a protein which regulates the cell cycle progression
to ensure normal cell division, growth, and development. However, in cancer, changes in the …

Cornification and epidermal barrier defects are associated with a number of clinically
diverse skin disorders. However, a suitable in vitro model for studying normal barrier …

Studies have established that autophagy constitutes an efficient process to recycle cellular
components and certain proteins. The phenomenon was demonstrated primarily in …

Although p63 and MYC are important in the control of epidermal homeostasis, the
underlying molecular mechanisms governing keratinocyte proliferation or differentiation …

The transcription factor p63 is a key mediator of epidermal development. Point mutations in
p63 in patients lead to developmental defects, including orofacial clefting. To date …