Cancer is a heavy burden for humans across the world with high morbidity and mortality.
Transcription factors including sex determining region Y (SRY)-related high-mobility group …

Sox transcription factors play widespread roles during development; however, their versatile
funtions have a relatively simple basis: the binding of a Sox protein alone to DNA does not …

The transcription factor Sox9 was first discovered in patients with campomelic dysplasia, a
haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 …

Background Articular cartilage defects are a veritable therapeutic problem because
therapeutic options are very scarce. Due to the poor self-regeneration capacity of cartilage …

Maintain stemness, commit to a specific lineage, differentiate, proliferate, or die. These are
essential decisions that every cell is constantly challenged to make in multi-cellular …

The transcription factor SOX9 is essential for the development of multiple organs including
bone, testis, heart, lung, pancreas, intestine and nervous system. Mutations in the human …

Osteoarthritis (OA), the most common aging-related joint disease, is caused by an
imbalance between extracellular matrix synthesis and degradation. Here, we discover that …

Sox proteins are found in all metazoans and are active in many developmental processes.
Their function as transcription factors is governed by their DNA-binding properties as much …

Die fortgesetzte Suche nach dem einzelnen ‚geschlechtsdeterminierenden Gen ': SRY als
TDF? 250 Downstream von SRY–weitere Gene, die hierarchisch unterhalb von SRY als an …

Cell-fate determination of pluripotent cells, cell proliferation, differentiation, and maturation,
as well as the maintenance of stem cells, are essential cellular events during …